Exploring Genetic Literacy in a Small Hispanic Population

Subasic, Kimberly; Kronk, Rebecca; Mantione, Andrea; Vital, María Macarena Zamorano

doi:10.1177/1043659620938127

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…It is well-suited for the German sample but proves to be too demanding for the Greek group, as indicated by a significant floor effect. When examining other samples where the KGEI and KMGG have been employed, it becomes apparent that the KGEI tends to have a moderate level of difficulty, while the KMGG appears relatively challenging ( Carver et al, 2017 ; Gericke et al, 2017 ; Tornabene et al, 2020 ; Subasic et al, 2021 ), which aligns with the findings in our samples. Carver et al (2017) reported that the difficulty of the KMGG was associated with items related to epigenetics, which posed significant challenges for participants but were retained to reflect the current state of research.…”

Section: Discussionsupporting

confidence: 85%

“…While Carver et al (2017), Tornabene et al (2020), andGericke et al (2017) reported internal consistency values ranging from 0.61 to 0.69 for the KGEI and KMGG, we observed substantially higher values. Similarly, the Spanish translation by Subasic et al (2021) reported 0.782 for the KGEI and 0.926 for the KMGG, although it is important to acknowledge that Subasic's sample was relatively small, consisting of only 20 participants.…”

Section: Internal Consistency and Retestmentioning

confidence: 98%

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Translation, validation, and comparison of genetic knowledge scales in Greek and German

Melchior,

Beyreuther,

Teichmann

2024

Front. Genet.

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Introduction: Advances in biosciences have significantly expanded our knowledge and capabilities in medicine and technology. Genetic tests can now predict hereditary predisposition or susceptibility to diseases, while gene-editing tools like CRISPR/Cas enable easy repair of disease genes in both somatic and germline cells, ensuring permanent genome correction. Despite these advancements, there is a shortage of valid instruments for studying the knowledge about these technologies. To fill this gap, our study aims to translate and validate various scales to effectively measure the public’s knowledge of genetics.Methods: A convenience sample of N = 567 (Germany n = 317, Greece n = 250) participants completed a Google Forms questionnaire between December 2022 and June 2023, which included the General Knowledge of Genes and Heredity (GKGH), Knowledge about Gene-Environment Interaction (KGEI), and Knowledge of Modern Genetics and Genomics (KMGG) questionnaires. Analyses included internal consistency, structural validity, construct validity, and retest reliability with a subset of n = 72 (DE) and n = 50 (GR). Correlation analyses and group differences were evaluated for gender, education, religiosity, age, prior experience with genetic testing, and preferences toward potential providers of genetic testing. This study used the STROBE checklist for reporting.Results: The GKGH exhibited low values in internal consistency and item analysis, along with a ceiling effect within the German group. However, it demonstrated good values in retest and construct validity. In the Greek group, all properties were highly satisfactory. The KMGG consistently displayed excellent properties across all analyses, whereas the KGEI only showed convincing results in construct validity and item analysis.Discussion: The GKGH and KMGG demonstrated strong psychometric properties with varying difficulty levels dependent on the sample, with the German sample demonstrating a notably higher understanding of genetic technologies. Despite displaying acceptable properties, the KGEI fell short of measuring what its title suggests. Participants’ level of education showed a significant correlation with knowledge of genetic technologies, and only in the Greek sample did experiences with genetic tests influence knowledge. Preferences regarding availability of genetic testing are comparable between the two countries, with variations influenced by factors such as age, gender and religiosity.

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Section: Discussionsupporting

confidence: 85%

Section: Internal Consistency and Retestmentioning

confidence: 98%

Translation, validation, and comparison of genetic knowledge scales in Greek and German

Melchior,

Beyreuther,

Teichmann

2024

Front. Genet.

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“…While the importance of genetic testing has recently emerged within the context of personalized medicine, there have been limited studies on genetic testing strategies for Mexican-origin adults and no studies to date specifically for men ( 13 – 16 ). However, low levels of knowledge and awareness about genetic testing have previously been reported ( 16 ), and prior findings demonstrate that Hispanics may not understand risk within the context of genetics due to limited genetic literacy defined as the ability to obtain, process, understand, and use genetic information ( 17 , 18 ). This may be due in part to limited health care access and health information faced by many Hispanics in the U.S. ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Communicating PNPLA3 genetic risk status for NAFLD among Mexican-origin men

Villavicencio

Maldonado²,

Crocker³

et al. 2023

Front. Public Health

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IntroductionThe burden of non-alcoholic fatty liver disease (NAFLD) continues to disproportionately impact under-resourced communities in the U.S., particularly Mexican-origin populations. Genetic polymorphisms such as the rs738409 C/G variant in patatin-like phospholipase domain-containing 3 (PNPLA3) have been associated with higher prevalence of and progression along the NAFLD spectrum. This qualitative study conducted in the U.S. Southwest aimed to assess Mexican-origin men's experience receiving genetic testing for PNPLA3 risk carrier status.MethodsSemi-structured interviews were conducted with 17 Mexican-origin men whose NAFLD status and genetic predisposition were determined as part of a previous cross-sectional study. The interview guide included questions exploring participants' insights on how genetic risk status was delivered, how the information influenced their motivation for lifestyle modification to reduce NAFLD risk, and any knowledge sharing that occurred with family members after learning of their PNPLA3 risk status. Interviews were conducted and audio recorded in English (n = 6) and Spanish (n = 11) and uploaded into NVivo software for data analysis and interpretation. Guided by the Health Belief Model, a thematic analysis approach was used to identify primary themes.ResultsResults highlighted men's preference for receiving this type of genetic risk information through a letter sent to their homes. General comprehension of PNPLA3 risk status was deemed high and most men stated sharing their genetic predisposition to NAFLD with their immediate family members. Participants also indicated that family and awareness of this genetic risk acted as primary motivators for implementing behavior changes (e.g., diet, physical activity) toward the prevention of more severe liver conditions.DiscussionFindings from this qualitative study suggest the feasibility of communicating genetic risk for NAFLD among Mexican-origin men. Future strategies for the dissemination of genetic risk results among Mexican-origin individuals should consider familial and cultural appropriate strategies.

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Exploring Genetic Literacy in a Small Hispanic Population

Cited by 2 publications

References 16 publications

Translation, validation, and comparison of genetic knowledge scales in Greek and German

Translation, validation, and comparison of genetic knowledge scales in Greek and German

Communicating PNPLA3 genetic risk status for NAFLD among Mexican-origin men

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