Exploring heterometallic bridged Pt(II)-Zn(II) complexes as potential antitumor agents

Soldatović, Tanja; Šmit, Biljana; Mrkalić, Emina; Matić, Sanja; Jelić, Ratomir; Serafinović, Marina Ćendić; Gligorijević, Nevenka; Čavić, Milena; Aranđelović, Sandra; Grgurić-Šipka, Sanja

doi:10.1016/j.jinorgbio.2022.112100

Cited by 7 publications

(23 citation statements)

References 48 publications

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“…The elemental analyses, UV–Vis, IR, 1 H, 13 C NMR and ESI‐MS spectroscopy were used for characterization of the synthesized C1a–C4a complexes (Supporting Information, see Figures S1 and S2). The synthetic pathway for the preparation of complexes is the same as published before for heterometallic complexes that contain unsubstituted 2,2′;6′,2″‐terpyridine inert ligand 3 …”

Section: Resultsmentioning

confidence: 99%

“…The complexes C1a–C4a were synthesized following already published procedures. 3 . Generally, to solutions of cis ‐[PtCl 2 (NH 3 ) 2 ] or trans ‐[PtCl 2 (NH 3 ) 2 ] (0.036 g, 0.12 mmol, 20 ml H 2 O) a less than one equivalent of AgClO 4 (0.0249 g, 0.12 mmol) was added dropwise.…”

Section: Methodsmentioning

confidence: 99%

“…The 3 ml aliquots were taken for measuring of pH and to record spectra after each addition of NaOH and were returned back after use. The titration data were fitted to the equation for the determination of both p K a values, 3 and obtained data are shown in Table 1.

y goodbreak= a goodbreak+ ((), b goodbreak- a) / ((), 1 goodbreak+ 2.718 * ((), ((), x goodbreak- italicpKa 1) / m)) goodbreak+ ((), c goodbreak- b) / true(1 goodbreak+ 2.718 * ((), (x - pKa 2 / n))

…”

Section: Methodsmentioning

confidence: 99%

“…Four novel heterometallic complexes with adopted formula cis ‐ and trans‐ Pt(II)‐L‐Zn(II) (where L = 4,4′‐bipyridyl or pyrazine) regarding to their potential antitumor activity were investigated in our previous work. The obtained results have shown that newly synthesized [{ trans ‐PtCl(NH 3 ) 2 ( μ ‐4,4′‐bipy)ZnCl(terpy)}](ClO 4 ) 2 exhibited greater selective cytotoxicity toward HCT‐116 (human colorectal cancer) cells higher than cisplatin 3 …”

Section: Introductionmentioning

confidence: 96%

“…On the other side, zinc(II) is a bio‐essential transition metal ion with important role in biological processes, like the growth and death of organisms DNA synthesis, gene expression, immune function, enzymatic reactions, protein synthesis, wound healing and some disease such as inflammatory bowel disease 2 . Heterometallic complexes of Pt(II) and Zn(II) ions are designed to improve the anticancer properties of metallodrugs, bearing in mind the significant role of zinc(II) in biological processes 3 …”

Section: Introductionmentioning

confidence: 99%

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Heterometallic bridged Pt(II)‐Zn(II) complexes: Influence of the substituent in 4′‐position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules

Serezlić,

Hasić,

Ašanin

et al. 2024

Applied Organom Chemis

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The synthesis and characterization of novel hetrometallic complexes [{cis‐PtCl(NH3)2(μ‐4,4′‐bipyridyl)ZnCl(terpy‐Cl)}](ClO4)2 (C1a), [{trans‐PtCl(NH3)2(μ‐4,4′‐bipyridyl)ZnCl(terpy)}](ClO4)2 (C2a), [{cis‐PtCl(NH3)2(μ‐pyrazine)ZnCl(terpy‐Cl)}](ClO4)2 (C3a) and [{trans‐PtCl(NH3)2(μ‐pyrazine)ZnCl(terpy‐Cl)}](ClO4)2 (C4a) (where terpy‐Cl = 4′‐chloro‐2,2′:6′,2′′‐terpyridine) was done. Acid–base titrations were performed by UV–Vis spectrophotometric method to evaluate the pKa values of corresponding aqua complexes. Interactions between complexes and important biomolecules, guanosine‐5′‐monophosphate (5′‐GMP) and glutathione (GSH) were examined by 1H NMR spectroscopy. The chloride substituent at the 4′ position on the middle pyridine ring of terpyridine ligand significantly affects the coordination of biomolecules, as well as overall stability of complexes. The complexes were evaluated in vitro for the antioxidant prevention of DNA damages. All tested novel complexes demonstrated a significant reduction in DNA damage against oxidative modifications of DNA caused by the hydroxyl and peroxyl radicals. Also, cytotoxicity evaluation showed that significant cytotoxicity occurs only after long‐term effect of C1a, C2a and C3a, complexes in HCT‐116 cells. Molecular docking studies predict results in agreement with experimental research.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%