Exploring indole derivatives as myeloid cell leukaemia-1 (Mcl-1) inhibitors with multi-QSAR approach: a novel hope in anti-cancer drug discovery

Abstract

In human, the over-expression of Mcl-1 protein causes the different cancers and it is also responsible for cancer resistance to different cytotoxic agents. Thus, discovery of potential inhibitors of Mcl-1...

An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives

“…No in vitro or in vivo study against PLpro has been found during the preparation of this manuscript but several in silico studies have been performed in search of potential compounds against PLpro. 133–136…”

“…[130][131][132] No in vitro or in vivo study against PLpro has been found during the preparation of this manuscript but several in silico studies have been performed in search of potential compounds against PLpro. [133][134][135][136] 7.1.2.2 RdRp. RdRp is the most crucial enzyme in the RNA virus family as it mediates the transcription and replication of the RNA genome during infection which facilitates the chance to use it as a drug target.…”

Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies

“…For example, the tubulin inhibitors vincristine and vinblastine isolated from Catharanthus roseus are used in the treatment of various cancers [ 26 ], whereas dacomitinib is a well-known antitumor agent that blocks the activity of epidermal growth factor receptor (EGFR) [ 27 ]. Furthermore, indole derivatives have been identified as potent myeloid cell leukemia-1 (Mcl-1) [ 28 ] or Pim kinase [ 29 ] inhibitors. Antiproliferative effects of the indole-based compounds may also result from the selective inhibition of silent information regular sirtuin 1 (SIRT1) protein, a highly conserved NAD + -dependent deacetylase belonging to the sirtuin family [ 30 ], as well as σ 2 receptors, the expression of which is increased in tumor cells with respect to quiescent cells.…”