Exploring Influences on Theory of Mind Impairment in Opioid Dependent Patients

Eidenmueller, Katharina; Grimm, Franz; Hermann, Derik; Frischknecht, Ulrich; Montag, Christiane; Dziobek, Isabel; Kiefer, Falk; Bekier, Nina Kim

doi:10.3389/fpsyt.2021.721690

Cited by 4 publications

(2 citation statements)

References 74 publications

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“…Data collection and diagnostic procedures also were performed by trained medical staff and a senior psychiatrist. A study description of sample 2 has previously been published ( 45 ).…”

Section: Methodsmentioning

confidence: 99%

A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders

et al. 2022

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RationaleChildhood maltreatment (CM) leads to detrimental mental health outcomes, such as substance use disorders (SUD). This study examined prevalence and severity of all five types of CM with respect to specific substances and sex in treatment-seeking individuals with SUD. The influences of type of CM and symptoms of depressiveness, anxiety, and perceived stress on substance craving at admission as well as craving reduction during SUD treatment were examined.MethodsN = 546 patients in treatment for SUD and N = 109 individuals in opioid maintenance treatment filled out questionnaires regarding CM (Childhood Trauma Questionnaire) and psychopathologies. Substance craving was assessed throughout treatment using the Mannheim Craving Scale. Group differences in CM, type of substance and sex were examined. General linear models were applied to examine influences on substance craving.ResultsHigher prevalence and severity of all five subtypes of CM were observed in individuals with SUD compared to the general population. Women were more severely affected by emotional and sexual abuse than men. Patients with cannabis use disorder reported more severe experiences of emotional abuse compared to all other substances. Craving at admission to treatment was influenced by emotional abuse, however, symptoms of depressiveness, anxiety, and perceived stress contributed to craving at admission or craving reduction during treatment.ConclusionCM relates to SUD and should be incorporated in prevention and treatment of SUD. Underlying mechanisms of the association might relate to impairments in processing and regulation of stress, emotions, and interpersonal relations following a history of CM.

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“…Data collection and diagnostic procedures also were performed by trained medical staff and a senior psychiatrist. A study description of sample 2 has previously been published ( 45 ).…”

Section: Methodsmentioning

confidence: 99%

A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders

et al. 2022

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“…In animals, μopioid agonists also influence the social approach and withdrawal behavior depending on the dose, duration of dosing, and the social context [8]. Clinical studies in humans have shown that opiate addicts under low-dose opiate maintenance treatment display deficits of social interaction and social cognition with autism-like behaviors [8,[26][27][28]. Moreover, opioid antagonists may improve hyperactivity and restlessness symptoms in autism [4,29].…”

Section: Introductionmentioning

confidence: 99%

Dopamine D2R and opioid MOR availability in autism spectrum disorder

Noppari,

Tuisku,

Lukkarinen

et al. 2024

Preprint

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Opioid and dopamine receptor systems are implicated in the pathoetiology of autism, but in vivo human brain imaging evidence for their role remains elusive. Here, we investigated regional type 2 dopamine and mu-opioid receptor (D2R and MOR, respectively) availabilities and regional interactions between the two neuromodulatory systems associated with autism spectrum disorder (ASD). In vivo positron emission tomography (PET) with radioligands [11C]raclopride (D2R) and [11C]carfentanil (MOR) was carried out in 16 adult males with high functioning ASD and 19 age and sex matched controls. Regional group differences in D2R and MOR receptor availabilities were tested with linear mixed models and associations between regional receptor availabilities were examined with correlations. There were no group differences in whole-brain voxel-wise analysis of DR2 but ROI analysis presented a lower overall mean D2R availability in striatum of the ASD versus control group. Post hoc regional analysis revealed reduced D2R availability in nucleus accumbens of the ASD group. The whole-brain voxel-wise analysis of MOR revealed precuneal up-regulation in the ASD group, but there was no overall group difference in the ROI analysis for MOR. MOR down-regulation was observed in the hippocampi of the ASD group in a post hoc analysis. Regional correlations between D2R and MOR availabilities were weaker in the ASD group versus control group in the amygdala and nucleus accumbens. These alterations may translate to disrupted modulation of social motivation and reward in ASD.

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Dissecting shared pain representations to understand their behavioral and clinical relevance

Rütgen,

Lamm

2024

Neuroscience & Biobehavioral Reviews

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Exploring Influences on Theory of Mind Impairment in Opioid Dependent Patients

Cited by 4 publications

References 74 publications

A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders

A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders

Dopamine D2R and opioid MOR availability in autism spectrum disorder

Dissecting shared pain representations to understand their behavioral and clinical relevance

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