This paper investigates the challenges and opportunities arising from incommensurate spatial partitions (ISPs) in regional science and spatial econometrics, focusing on how processes with overlapping yet distinct boundaries, interact and influence each other. ISPs are prevalent in various domains, including housing markets, employment centers, voting districts, and educational institutions, often complicating spatial econometric modeling and analysis. Using the intersection of school catchment areas and neighborhoods as a primary case study, the paperintroduces a novel methodological framework utilizing bipartite graphs.This approach reframes the relationship between different spatial units,allowing for the analysis of multi-process spatial contexts withoutneeding harmonization of spatial supports. The paper also develops newspatial weights derived from the bipartite graph, facilitating bothexploratory spatial data analysis and confirmatory spatial econometricmodeling. The paper's contributions include a set of new modelspecifications that consider spillovers from and to each of theprocesses involved, demonstrating the application of these methodsthrough a case study in San Diego, California. This involves analyzing198 neighborhoods and 370 public elementary school catchments, exploringthe implications of school-neighborhood interactions on educational outcomes and neighborhood characteristics.