Exploring multifunctional antioxidants as potential agents for management of neurological disorders

Sindhu, Rakesh K.; Kaur, Parneet; Singh, Harmanpreet; Batiha, Gaber El‐Saber; Verma, Inderjeet

doi:10.1007/s11356-021-17667-0

Cited by 26 publications

(13 citation statements)

References 168 publications

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“…Cells have several enzymatic and nonenzymatic antioxidant defense systems to protect themselves from the deleterious effect of excessive ROS. Cells produce the enzymes glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase, which scavenge and neutralize the ROS. , For instance, a superoxide anion that is produced during oxidative phosphorylation in the mitochondrial respiratory chain, specifically in the pathological condition, is converted to H 2 O 2 by either SOD2 in the matrix of mitochondria or SOD1 in the mitochondrial inner-membrane space and cytosol . Subsequently, H 2 O 2 is reduced to H 2 O by mitochondrial and cytosolic glutathione peroxidase (GPX).…”

Section: Introductionmentioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.

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Section: Introductionmentioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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“…In general, therapeutic approaches using free radical scavengers (antioxidants) have shown promise in preventing, retarding, managing, or improving many complex diseases, especially neurodegeneration and cardiovascular diseases. As evidenced in different research, antioxidants may play a significant role in preventing or reducing cellular damage and further alterations occurring in cells, such as dysfunction of mitochondria, mutations in DNA, and lipid peroxidation in the cell membrane [ 43 , 44 ]. ROS are omnipresent signaling molecules in biological systems.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Antioxidant, Antimicrobial, and Anti-Inflammatory Properties of Origanum compactum Benth Essential Oils from Two Regions: In Vitro and In Vivo Evidence and In Silico Molecular Investigations

et al. 2022

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The purposes of this investigatory study were to determine the chemical composition of the essential oils (EOs) of Origanum compactum from two Moroccan regions (Boulemane and Taounate), as well as the evaluation of their biological effects. Determining EOs’ chemical composition was performed by a gas chromatography–mass spectrophotometer (GC-MS). The antioxidant activity of EOs was evaluated using free radical scavenging ability (DPPH method), fluorescence recovery after photobleaching (FRAP), and lipid peroxidation inhibition assays. The anti-inflammatory effect was assessed in vitro using the 5-lipoxygenase (5-LOX) inhibition test and in vivo using the carrageenan-induced paw edema model. Finally, the antibacterial effect was evaluated against several strains using the disk-diffusion assay and the micro-dilution method. The chemical constituent of O. compactum EO (OCEO) from the Boulemane zone is dominated by carvacrol (45.80%), thymol (18.86%), and α-pinene (13.43%). However, OCEO from the Taounate zone is rich in 3-carene (19.56%), thymol (12.98%), and o-cymene (11.16%). OCEO from Taounate showed higher antioxidant activity than EO from Boulemane. Nevertheless, EO from Boulemane considerably inhibited 5-LOX (IC50 = 0.68 ± 0.02 µg/mL) compared to EO from Taounate (IC50 = 1.33 ± 0.01 µg/mL). A similar result was obtained for tyrosinase inhibition with Boulemane EO and Taounate EO, which gave IC50s of 27.51 ± 0.03 μg/mL and 41.83 ± 0.01 μg/mL, respectively. The in vivo anti-inflammatory test showed promising effects; both EOs inhibit and reduce inflammation in mice. For antibacterial activity, both EOs were found to be significantly active against all strains tested in the disk-diffusion test, but O. compactum EO from the Boulemane region showed the highest activity. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for O. compactum EO from the Boulemane region ranged from 0.06 to 0.25% (v/v) and from 0.15 to 0.21% (v/v) for O. compactum from the Taounate region. The MBC/MIC index revealed that both EOs exhibited remarkable bactericidal effects.

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“…Of interest, GDF15 could be a promoter of COVID-19 tolerance in the early phase of SARS-CoV-2 infection to a detrimental factor in the propagation of the cytokine storm [ 32 , 34 ]. Thus, in virtue of the anti-inflammatory action of GDF15, recombinant GDF15 might be of therapeutic value against the SARS-CoV-2 infection-induced hyperinflammation [ 32 , 35 ].…”

Section: Growth Differentiation Factor 15 and Covid-19mentioning

confidence: 99%

The Potential Role of Growth Differentiation Factor 15 in COVID-19: A Corollary Subjective Effect or Not?

et al. 2022

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Coronavirus disease 2019 (COVID-19) is primarily caused by various forms of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants. COVID-19 is characterized by hyperinflammation, oxidative stress, multi-organ injury (MOI)-like acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Different biomarkers are used in the assessment of COVID-19 severity including D-dimer, ferritin, lactate dehydrogenase (LDH), and hypoxia-inducible factor (HIF). Interestingly, growth differentiation factor 15 (GDF15) has recently become a potential biomarker correlated with the COVID-19 severity. Thus, this critical review aimed to determine the critical association between GDF15 and COVID-19. The perfect function of GDF15 remains not well-recognized; nevertheless, it plays a vital role in controlling cell growth, apoptosis and inflammatory activation. Furthermore, GDF15 may act as anti-inflammatory and pro-inflammatory signaling in diverse cardiovascular complications. Furthermore, the release of GDF15 is activated by various growth factors and cytokines including macrophage colony-stimulating factor (M-CSF), angiotensin II (AngII) and p53. Therefore, higher expression of GDF15 in COVID-19 might a compensatory mechanism to stabilize and counteract dysregulated inflammatory reactions. In conclusion, GDF15 is an anti-inflammatory cytokine that could be associated with the COVID-19 severity. Increased GDF15 could be a compensatory mechanism against hyperinflammation and exaggerated immune response in the COVID-19. Experimental, preclinical and large-scale clinical studies are warranted in this regard.

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Exploring multifunctional antioxidants as potential agents for management of neurological disorders

Cited by 26 publications

References 168 publications

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Chemical Composition and Antioxidant, Antimicrobial, and Anti-Inflammatory Properties of Origanum compactum Benth Essential Oils from Two Regions: In Vitro and In Vivo Evidence and In Silico Molecular Investigations

The Potential Role of Growth Differentiation Factor 15 in COVID-19: A Corollary Subjective Effect or Not?

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