Exploring nanoselenium to tackle mutated SARS-CoV-2 for efficient COVID-19 management

Abstract

Despite ongoing public health measures and increasing vaccination rates, deaths and disease severity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new emergent variants continue to threaten the health of people around the world. Therefore, there is an urgent need to develop novel strategies for research, diagnosis, treatment, and government policies to combat the variant strains of SARS-CoV-2. Since the state-of-the-art COVID-19 pandemic, the role of selenium in dealing with COVID-19 disease has been widely discussed due to its importance as an essential micronutrient. This review aims at providing all antiviral activities of nanoselenium (Nano-Se) ever explored using different methods in the literature. We systematically summarize the studied antiviral activities of Nano-Se required to project it as an efficient antiviral system as a function of shape, size, and synthesis method. The outcomes of this article not only introduce Nano-Se to the scientific community but also motivate scholars to adopt Nano-Se to tackle any serious virus such as mutated SARS-CoV-2 to achieve an effective antiviral activity in a desired manner.

Exploring the fluorescence properties of tellurium-containing molecules and their advanced applications

“…This thorough exploration spans various domains, including biological, coordination, and materials sciences. [51][52][53][54][55][56][57][58][59] The collective study of chalcogens not only deepens our understanding of their unique properties and interactions but also initiates a transformative shift, highlighting their distinct roles in the scientific landscape. 60,61 The unique characteristics of chalcogens, specifically Se and Te, encompass a diverse range of oxidation states, 62 a strong tendency to form compounds with metals and nonmetals, 63,64 ease of introduction and removal into molecular organic scaffolds, 65,66 distinctive ligand field geometries, 67,68 adherence to hard-soft acid-base principles, 69,70 preferred donor atoms, 71 and the ability to participate in redox reactions, 72,73 making them valuable in the field of fluorescence applications in biomedical and environmental contexts.…”

Aspects of Nanotechnology for COVID-19 Vaccine Development and Its Delivery Applications

“…Ads’ traits and benefits are present in AAV as well. In a phase I/II COV001 experiment, ChAdOx1 nCoV-19 (AZD1222), an Ad-based recombinant vaccine created at the University of Oxford in Oxford, UK, was discovered to be resistant, and a potent immune response to SARS-CoV-2 was produced in all participants [ 68 ]. Nearly all the patients who received AZD1222 displayed a four-fold increase in the antibody’s ability to neutralize the SARS-CoV-2 S protein [ 12 ].…”

“…Nearly all the patients who received AZD1222 displayed a four-fold increase in the antibody’s ability to neutralize the SARS-CoV-2 S protein [ 12 ]. Additionally, AZD1222 usage has not been associated with any negative side effects of note [ 68 ].…”

“…Nano-Se has excellent antiviral efficiency with the potential to neutralize and eradicate SARS-CoV-2 variants. However, further research needs to be investigated [ 68 ].…”

A Novel Vision of Reinforcing Nanofibrous Masks with Metal Nanoparticles: Antiviral Mechanisms Investigation

“…SeNPs have the potential of being a part of protective and treatment strategies on the battlefield of viral infections. However, further laboratory and clinical studies are required for moving forward in this direction [ 142 ].…”