Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance

Chu, Siwei; Stochaj, Ursula

doi:10.20517/cdr.2020.20

Cited by 8 publications

(10 citation statements)

References 261 publications

(434 reference statements)

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“…Cell-directed delivery of antiapoptotic drugs can be achieved by using nanoparticles, which hold great promise because improved drug dissolution and stability can be achieved using nanoparticle-mediated drug delivery. Moreover, nanoparticles enable delivery of multiple drugs simultaneously coupled with real-time monitoring features both actively and passively in the tumor tissues (Chu & Stochaj, 2020;Hassanin & Elzoghby, 2020;Ulldemolins et al, 2021). Studies are ongoing to optimize the formulations, improve the drug release kinetics, and for improving safety and efficacy.…”

Section: Decitabinementioning

confidence: 99%

Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis

Halder

2024

IJALSR

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Chemotherapy resistance indicates the non-responsiveness of cancer cells to the cytotoxic and inhibitory effects of chemo drugs attributed to either intrinsic or extrinsic resistance mechanisms in cancer cells. Studies so far indicate that drug resistance can be triggered by a multitude of factors such as the over-expression of drug efflux pumps, DNA repair mechanisms, modifications in the drug target such as point mutations and gene amplification, over-expression of anti-apoptotic proteins and down-regulation of pro-apoptotic signals, presence of cancer stem cells and immune-suppressive cells, excessive cytokine production, tumor heterogeneity, epigenetic changes, activation of alternate pro-survival signaling pathways, etc. Both host and tumor-related factors can contribute to therapy resistance. Currently, chemo resistance poses the foremost setback in the successful treatment of cancer, and it exerts significant stress on the available medical resources. Besides the costs associated with the treatment, patients go through severe emotional and physical trauma. Chemotherapy resistance is also a major contributor to accelerated metastasis and invasion. Dose-escalation is not always practical since the associated side effects may increase apart from increasing the treatment costs. Several studies are ongoing to address this issue productively, such as therapeutic molecules designed to restore the apoptotic machinery. Site-specific delivery of pro-apoptotic agents such as small molecules, antibodies, peptides, etc. targeting the apoptosis pathway is also thoroughly studied. Moreover, the efficacy of combination strategies is also a topic of research.

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Section: Decitabinementioning

confidence: 99%

Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis

Halder

2024

IJALSR

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“…Potential future applications of metal-based NPs such as gold, silver, and magnetic NPs in diagnosis and therapy could advance the development and use of nanomedicines on a larger scale. For example, AuNPs have garnered a lot of attention, as they appear to be readily absorbed by soft tumor tissues and render the tumor more susceptible to radiation (e.g., in the near-infrared)-based heat therapy for selective elimination [ 219 , 220 ]. Most of these materials are biocompatible and stable, and they fulfill specialized applications that need qualities that organic materials cannot provide.…”

Section: The Future Of Nanomedicinementioning

confidence: 99%

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Waheed

Zhang

et al. 2022

J Nanobiotechnol

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The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and safety. NPs are intriguing when considering medical applications because of their essential and unique qualities, including a significantly higher surface to mass ratio, quantum properties, and the potential to adsorb and transport drugs and other compounds. However, NPs must overcome or navigate several biological barriers of the human body to successfully deliver drugs at precise locations. Engineering the drug carrier biointerface can help overcome the main biological barriers and optimize the drug delivery in a more personalized manner. This review discusses the significant heterogeneous biological delivery barriers and how biointerface engineering can promote drug carriers to prevail over hurdles and navigate in a more personalized manner, thus ushering in the era of Precision Medicine. We also summarize the nanomedicines' current advantages and disadvantages in drug administration, from natural/synthetic sources to clinical applications. Additionally, we explore the innovative NP designs used in both non-personalized and customized applications as well as how they can attain a precise therapeutic strategy.

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“…This generates high local temperatures that induce thermal ablation of tumor cells [ 44 , 45 , 46 ]. GO has demonstrated effectiveness as a PA for cancer PTT [ 47 , 48 , 49 ]. Moreover, GO functionalized with PEG and combined with near-infrared (NIR) irradiation has potential as a biocompatible smart nanocarrier in colon cancer cells [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of Graphene Oxide Nanoparticles: Effects on Liver Enzymes and Cardiovascular System in Animal Models and Skeletal Muscle Cells

Keremidarska-Markova,

Sazdova,

Ilieva

et al. 2024

Nanomaterials

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The growing interest in graphene oxide (GO) for different biomedical applications requires thoroughly examining its safety. Therefore, there is an urgent need for reliable data on how GO nanoparticles affect healthy cells and organs. In the current work, we adopted a comprehensive approach to assess the influence of GO and its polyethylene glycol-modified form (GO-PEG) under near-infrared (NIR) exposure on several biological aspects. We evaluated the contractility of isolated frog hearts, the activity of two rat liver enzymes–mitochondrial ATPase and diamine oxidase (DAO), and the production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells following direct exposure to GO nanoparticles. The aim was to study the influence of GO nanoparticles at multiple levels—organ; cellular; and subcellular—to provide a broader understanding of their effects. Our data demonstrated that GO and GO-PEG negatively affect heart contractility in frogs, inducing stronger arrhythmic contractions. They increased ROS production in C2C12 myoblasts, whose effects diminished after NIR irradiation. Both nanoparticles in the rat liver significantly stimulated DAO activity, with amplification of this effect after NIR irradiation. GO did not uncouple intact rat liver mitochondria but caused a concentration-dependent decline in ATPase activity in freeze/thaw mitochondria. This multifaceted investigation provides crucial insights into GOs potential for diverse implications in biological systems.

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Exploring near-infrared absorbing nanocarriers to overcome cancer drug resistance

Cited by 8 publications

References 261 publications

Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis

Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Comprehensive Assessment of Graphene Oxide Nanoparticles: Effects on Liver Enzymes and Cardiovascular System in Animal Models and Skeletal Muscle Cells

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