Exploring nitric oxide as a crucial prognostic biomarker of coronary artery disease

Adam, Lina N.; Oraha, Ashur Y.; Shekha, Mudhir Sabir; Al-Habib, Omar A.M.

doi:10.1016/j.prostaglandins.2023.106717

Cited by 6 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studying heterozygous (eNOS+/-) pregnant mice could provide meaningful information regarding the role of eNOS in PE. eNOS+/-mice have approximately 50% as much eNOS protein as WT mice [53], and this modest decrease in eNOS is comparable to that associated with polymorphisms in the human eNOS gene [54][55][56]. Generally, eNOS+/-mice do not show obvious abnormalities except a slightly elevated BP without extra stress [57].…”

Section: Figurementioning

confidence: 78%

Endothelial Nitric Oxide synthase (eNOS) in Preeclampsia: An Update

2024

J Preg Child Health

View full text Add to dashboard Cite

Preeclampsia (PE) is a common pregnancy-related hypertensive disorder and is a leading cause of maternal and perinatal morbidity and mortality. The incidence of PE and its associated health care costs have been increasing in the United States over the past three decades. Pregnancies complicated by PE put both the mother and child at increased risk for chronic illnesses such as cardiovascular disease, cerebrovascular disease, and cognitive impairment later in life. To date, there is no effective treatment for PE and the etiology of PE is largely unknown. While human epidemiological studies have established an association between various genetic factors and PE, a causative link between genes associated with PE and PE development has been difficult to establish. Human studies have shown that variants in eNOS (endothelial nitric oxide synthase, also known as NOS3) gene are associated with PE, and animal experimental studies have provided evidence to show the potential functional connection between the eNOS gene and PE. Here we review several studies that investigated the role of eNOS in PE, as well as studies that described how manipulating the eNOS/NO pathway could aid in disease intervention.

show abstract

Section: Figurementioning

confidence: 78%

Endothelial Nitric Oxide synthase (eNOS) in Preeclampsia: An Update

2024

J Preg Child Health

View full text Add to dashboard Cite

show abstract

“…The detailed baseline characteristics of the study had been published previously [ 11 ]. The clinical data of the study are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The questionnaire included demographic and anthropometric data, risk factors for atherosclerosis, personal and family medical history, and details on current medication usage. Participants were specifically asked to report any medications taken, including the oral contraceptive pill and any medical treatments or COVID-19 vaccinations, received within the previous three months, as reported in our earlier study [ 11 ]. Approximately 10 mL of blood was collected from the all the subjects before the coronary angiography and/or surgery and stored in plain and EDTA vials.…”

Section: Methodsmentioning

confidence: 99%

Genetic and clinical study of myeloperoxidase's association with coronary artery disease

Adam,

Al-Habib,

Oraha

et al. 2024

Egypt Heart J

Self Cite

View full text Add to dashboard Cite

Background Unraveling myeloperoxidase’s (MPO) correlation with coronary artery disease (CAD) and genetic variations, this study seeks to enhance diagnostic precision and therapeutic strategies. Results CAD patients were found to be older and more male than controls. Several clinical parameters, including glucose, total bilirubin, alkaline phosphatase, creatinine, and troponin levels, showed significant variations. Moreover, CAD patients had lower red cell distribution width (RDW%) and mean platelet volume (MPV) than controls. Serum MPO levels did not differ significantly between CAD patients and controls, and no correlation was found with other clinical parameters except for glucose, creatinine, and total bilirubin. Conclusions The data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD. Trial registration: 15092021-9-12. Registered 15 September 2021.

show abstract

“…Environmental factors, such as exposure to pollutants from cigarette smoke or industrial emissions, can modulate NO production and are more pronounced in heavily industrialized areas [63,64]. Disease prevalence, which varies by region, can also impact NO levels; conditions like cardiovascular diseases have been linked to altered NO production [65]. NO production can be altered in infectious diseases such as viral infections [12], bacterial infections [66], fungal infections [67], and parasitic infections [68].…”

Section: Discussionmentioning

confidence: 99%

Association between Plasmodium Infection and Nitric Oxide Levels: A Systematic Review and Meta-Analysis

Kotepui,

Mahittikorn,

Wilairatana

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Nitric oxide (NO) has been implicated in the pathology of malaria. This systematic review and meta-analysis describe the association between NO levels and malaria. Embase, Ovid, PubMed, Scopus, and Google Scholar were searched to identify studies evaluating NO levels in malaria patients and uninfected controls. Meta-regression and subgroup analyses were conducted to discern differences in NO levels between the groups. Of the 4517 records identified, 21 studies were included in the systematic review and meta-analysis. The findings illustrated significant disparities in NO levels based on geographic location and study time frames. Despite the fluctuations, such as higher NO levels in adults compared to children, no significant differences in mean NO levels between patients and uninfected controls (p = 0.25, Hedge’s g: 0.35, 95% confidence interval (CI): −0.25–0.96, I2: 97.39%) or between severe and non-severe malaria cases (p = 0.09, Hedge’s g: 0.71, 95% CI: −0.11–1.54, I2: 96.07%) were detected. The systematic review and meta-analysis highlighted inconsistencies in NO levels in malaria patients. Given the high heterogeneity of the results, further studies using standardized metrics for NO measurements and focusing on biochemical pathways dictating NO responses in malaria are imperative to understand the association between NO and malaria.

show abstract

Exploring nitric oxide as a crucial prognostic biomarker of coronary artery disease

Cited by 6 publications

References 21 publications

Endothelial Nitric Oxide synthase (eNOS) in Preeclampsia: An Update

Endothelial Nitric Oxide synthase (eNOS) in Preeclampsia: An Update

Genetic and clinical study of myeloperoxidase's association with coronary artery disease

Association between Plasmodium Infection and Nitric Oxide Levels: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About