Exploring of InDel in bovine <i>PSAP</i> gene and their association with growth traits in different development stages

Wang, Shuhui; Zhao, Hailin; Wu, Mingli; Yi, Xiaohua; Chen, Pingbo; Liu, Shirong; Pan, Yun; Li, Qi; Tang, Xiaoqin; Sun, Xiuzhu

doi:10.1080/10495398.2020.1758122

Cited by 3 publications

(1 citation statement)

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“…At the same time, PSAP regulates caspase, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3’-kinase/AKT serine/threonine kinase 1 (PI3K/Akt), and transforming growth factor-β (TGF-β) pathways and has an important relationship with animal growth and development [ 17 ]. PSAP has been reported as a potential target gene in cattle breeding with functional single-nucleotide polymorphism (SNP) and insertion/deletion (InDels) loci associated with cattle morphological traits [ 18 , 19 ]. Considering their location, we speculate that the cattle PSAP gene also has other functional variations.…”

Section: Introductionmentioning

confidence: 99%

Functional Analysis of Haplotypes in Bovine PSAP Gene and Their Relationship with Beef Cattle Production Traits

Zhao

et al. 2020

Animals

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The purpose of this study was to explore functional variants in the prosaposin (PSAP) three prime untranslated region (3’ UTR) and clarify the relationship between the variants and morphological traits. Through Sanger sequencing, 13 variations were identified in bovine PSAP in four Chinese cattle breeds, with six of them being loci in 3’ UTR. In particular, Nanyang (NY) cattle had a special genotype and haplotype distribution compared to the other three breeds. NY cattle with ACATG and GCGTG haplotypes had higher morphological traits than GTACA and GTACG haplotypes. The results of dual-luciferase reporter assay showed that ACATG and GCGTG haplotypes affected the morphological traits of NY cattle by altering the secondary structure of PSAP 3’ UTR rather than the miR-184 target sites. The findings of this study could be an evidence of a complex and varying mechanism between variants and animal morphological traits and could be used to complement candidate genes for molecular breeding.

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Section: Introductionmentioning

confidence: 99%