Exploring oxidovanadium(<scp>iv</scp>) homoleptic complexes with 8-hydroxyquinoline derivatives as prospective antitrypanosomal agents

Scalese, Gonzalo; Machado, Ignacio; Correia, Isabel; Pessoa, João Costa; Bilbao, Lucía; Pérez-Díaz, Leticia; Gambino, Dinorah

doi:10.1039/c9nj02589h

Cited by 27 publications

(54 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…V V O-complexes were obtained in THF starting from [V IV O(acac) 2 ] and using equimolar ratio of reactants. Under the synthesis conditions, vanadium(IV) undergoes oxidation by molecular oxygen as previously reported for the homoleptic V V O-hydroxyquinoline derivatives [ 42 , 43 ].…”

Section: Resultsmentioning

confidence: 95%

“…Four bioactive oxidovanadium(V) heteroleptic compounds including 8HQ were developed and their biological behavior on T. cruzi was studied in detail [ 41 ]. More recently, two homoleptic series [V IV O(L-H) 2 ] and [V V O(OCH 3 )(L-H) 2 ], with L = 8-hydroxyquinoline derivatives, were studied in depth to shed light into the significance of the presence of the tridentate co-ligand on the biological behavior of the vanadium compounds [ 42 ]. Globally, results demonstrated the importance of the presence and nature of the tridentate coligand.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of Trypanosoma cruzi

et al. 2021

Self Cite

View full text Add to dashboard Cite

Five heteroleptic compounds, [VVO(IN-2H)(L-H)], where L are 8-hydroxyquinoline derivatives and IN is a Schiff base ligand, were synthesized and characterized in both the solid and solution state. The compounds were evaluated on epimastigotes and trypomastigotes of Trypanosoma cruzi as well as on VERO cells, as a mammalian cell model. Compounds showed activity against trypomastigotes with IC50 values of 0.29–3.02 μM. IN ligand and the new [VVO2(IN-H)] complex showed negligible activity. The most active compound [VVO(IN-2H)(L2-H)], with L2 = 5-chloro-7-iodo-8-hydroxyquinoline, showed good selectivity towards the parasite and was selected to carry out further biological studies. Stability studies suggested a partial decomposition in solution. [VVO(IN-2H)(L2-H)] affects the infection potential of cell-derived trypomastigotes. Low total vanadium uptake by parasites and preferential accumulation in the soluble proteins fraction were determined. A trypanocide effect was observed when incubating epimastigotes with 10 × IC50 values of [VVO(IN-2H)(L2-H)] and the generation of ROS after treatments was suggested. Fluorescence competition measurements with DNA:ethidium bromide adduct showed a moderate DNA interaction of the complexes. In vivo toxicity study on C. elegans model showed no toxicity up to a 100 μM concentration of [VVO(IN-2H)(L2-H)]. This compound could be considered a prospective anti-T. cruzi agent that deserves further research.

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of Trypanosoma cruzi

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides the ability to cleave/damage DNA, the binding interactions of vanadium complexes to DNA have also been studied by different techniques; for example electronic absorption [56,[59][60][61][62], circular dichroism [60][61][62], and fluorescence emission have been used frequently [42,[60][61][62]65]; other techniques such as atomic force microscopy [66][67][68][69], viscosity [56,[59][60][61]69] and have also been applied. 51 V NMR, [53,54] capillary electrophoresis and Fourier transform infrared difference spectroscopy [70] has also been used, but much less frequently, as well as DNA melting, applied to evaluate e.g., binding and/or DNA crosslink formation by the complexes [56,59,60,71].…”

Section: Binding To Dnamentioning

confidence: 99%

Misinterpretations in Evaluating Interactions of Vanadium Complexes with Proteins and Other Biological Targets

Pessoa

Correia

2021

Inorganics

Self Cite

View full text Add to dashboard Cite

In aqueous media, VIV- and VV-ions and compounds undergo chemical changes such as hydrolysis, ligand exchange and redox reactions that depend on pH and concentration of the vanadium species, and on the nature of the several components present. In particular, the behaviour of vanadium compounds in biological fluids depends on their environment and on concentration of the many potential ligands present. However, when reporting the biological action of a particular complex, often the possibility of chemical changes occurring has been neglected, and the modifications of the complex added are not taken into account. In this work, we highlight that as soon as most vanadium(IV) and vanadium(V) compounds are dissolved in a biological media, they undergo several types of chemical transformations, and these changes are particularly extensive at the low concentrations normally used in biological experiments. We also emphasize that in case of a biochemical interaction or effect, to determine binding constants or the active species and/or propose mechanisms of action, it is essential to evaluate its speciation in the media where it is acting. This is because the vanadium complex no longer exists in its initial form.

show abstract

“…Vanadium is among most significant environmental contaminants; being a hapten, it exerts adverse impacts on the cardiovascular, respiratory, and reproductive systems and produces neurotoxic and immune-toxic effects [3]. But at the same time, the latest achievements in medicine such as creation of vanadium-containing orthodontic / orthopedic implants and development of anti-parasitic, antiviral, anti-bacterial, antithrombotic, anti-hypertensive, hypolipidemic, spermicidal, anti-tuberculosis, antitumor, and anti-diabetic medications make it necessary to resolve disputable issues related to influence exerted by vanadium on the immune system [4][5][6][7][8][9]. Adverse consequences caused by effects produced by chemical environmental factors on human health can become apparent not only via immunedependent diseases occurrence but also fail-ure in body adaptation mechanisms.…”

mentioning

confidence: 99%

Vanadium in the environment as a risk factor causing negative modification of cell death (scientific review)

Dolgikh¹,

Dianova²,

Kazakova³

2020

Health Risk Analysis

View full text Add to dashboard Cite

The review dwells on results obtained via examinations that focused on effects produced by vanadium and its compounds contaminating the environment on health disorders related to cell death deregulation. Research works that have been performed over the last decades and focused on revealing the essence of apoptosis mechanism under exposure to technogenic chemicals are truly vital due to this phenomenon having great biological significance within a system of a body trying to adapt to influences exerted by environmental factors. The present work focuses on apoptosis peculiarities under exposure to excess technogenic concentrations of vanadium compounds. Published research works have been analyzed, analysis results are outlined, and a scientific hypothesis has been formulated within the subject matter. We have described an immune-modulating effect produced by vanadium compounds that is able to modify apoptosis events due to changes in cell death modes (apoptosis activation/inhibition) and it provides body adaptation to changing environmental conditions. A range in vanadium concentrations between essential and toxic ones predetermines multi-directional changes in apoptosis induction and completion. Thus, induced apoptosis activation makes for development of autoimmune and immune-proliferative processes; at the same time, cell death inhibition can result in immune deficiency, inflammatory reactions, and neurodegenerative diseases. It was shown that vanadium compounds produced modifying effects on mitochondrial functions regulation, changes in phosphorilation/dephosphorilation ratio in protein products, and imbalance in free radical processes; all this ultimately disrupts a balance between pro- and anti-apoptotic signals in a cell. Monitoring over apoptosis parameters that characterize cell death under exposure to vanadium and its compounds will allow timely detecting risks of pre-nosology state occurrence and prevent damage to health

show abstract

Exploring oxidovanadium(iv) homoleptic complexes with 8-hydroxyquinoline derivatives as prospective antitrypanosomal agents

Abstract: [VIVO(L-H)2] and [VVO(OCH3)(L-H)2] compounds of 8-hydroxyquinoline derivatives L showed activity against Trypanosoma cruzi and Leishmania infantum and high selectivities. Metallomics and interaction with BSA, apo-HTF and DNA were studied.

Cited by 27 publications

References 81 publications

Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of Trypanosoma cruzi

Heteroleptic Oxidovanadium(V) Complexes with Activity against Infective and Non-Infective Stages of Trypanosoma cruzi

Misinterpretations in Evaluating Interactions of Vanadium Complexes with Proteins and Other Biological Targets

Vanadium in the environment as a risk factor causing negative modification of cell death (scientific review)

Contact Info

Product

Resources

About