Exploring pain interference with motor skill learning in humans: a protocol for a systematic review

Matthews, David; Cancino, Edith Elgueta; Falla, Deborah; Khatibi, Ali

doi:10.1136/bmjopen-2020-045841

Cited by 2 publications

(5 citation statements)

References 53 publications

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“…In order to evaluate the quality of evidence, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used 55. The GRADE approach supports reporting on both the size of the effect and certainty of evidence 56. Reporting will use statements recommended by the GRADE working group 57.…”

Section: Methodsmentioning

confidence: 99%

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Can baseline features predict a reduction in pain and disability following neck-specific exercise in people with chronic non-specific neck pain?: A systematic review and meta-analysis protocol

et al. 2023

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IntroductionNeck-specific exercises (NSEs) are commonly used for the treatment of chronic non-specific neck pain (CNSNP). However, it remains unclear whether baseline features can predict the response to neck-specific exercise (NSE) in people with CNSNP. This systematic review aims to assess whether baseline features such as age, gender, muscle activity, fatigability, endurance and fear of movement can predict pain and disability reduction following a NSE intervention.Methods and analysisThis systematic review and meta-analysis will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Protocols guidelines checklist. The Web of Science, PubMed, Scopus, MEDLINE, Embase and CINAHL databases; key journals; and grey literature will be searched up until June 2023, including medical subject heading terms and keywords combinations. Included studies will investigate an association between the baseline features and pain and disability outcomes following NSE in people with CNSNP. Two independent reviewers will oversee the searching, screening, data extraction and assessment of risk of bias. The risk of bias will be assessed using the Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I) and Risk-Of-Bias tool for randomised trials 2 (ROB 2). The quality of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE). Using standardised forms, details regarding study characteristics, baseline features (predictive factors), intervention, primary outcome and effect size (OR and 95% CI of each predictive factor and p value) will be extracted from included studies. Meta-analyses will be considered, if the studies are sufficiently homogeneous and if three or more studies investigate the same or comparable factors that predict the same response (pain intensity or disability). In the event that less than three studies investigated the same factors, a narrative synthesis will be conducted.Ethics and disseminationEthical approval will not be required as this review will be based on published studies. The results of this study will be submitted to a peer-reviewed journal and presented at conferences.PROSPERO registration numberCRD42023408332.

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Section: Methodsmentioning

confidence: 99%

“… 55 The GRADE approach supports reporting on both the size of the effect and certainty of evidence. 56 Reporting will use statements recommended by the GRADE working group. 57 The size of effect will be reported using four categories: large effect; moderate effect; small important effect; and trivial, small unimportant effect or no effect.…”

Section: Methodsmentioning

confidence: 99%

Can baseline features predict a reduction in pain and disability following neck-specific exercise in people with chronic non-specific neck pain?: A systematic review and meta-analysis protocol

et al. 2023

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“…This systematic review followed a pre-defined published protocol [ 24 ] and is reported in concordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) [ 25 , 26 ]. The protocol was registered on PROSPERO (CRD42020213240) on 15th October 2020.…”

Section: Methodsmentioning

confidence: 99%

“…The eligibility criteria followed the PICOS framework and will be discussed briefly here; further details on inclusion and exclusion of studies are described in the protocol [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

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Exploring pain interference with motor skill learning in humans: A systematic review

et al. 2022

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Motor learning underpins successful motor skill acquisition. Although it is well known that pain changes the way we move, it’s impact on motor learning is less clear. The aim of this systematic review was to synthesize evidence on the impact of experimental and clinical pain on task performance and activity-dependent plasticity measures across learning and explore these findings in relation to different pain and motor learning paradigms. Five databases were searched: Web of Science, Scopus, MEDLINE, Embase and CINAHL. Two reviewers independently screened the studies, extracted data, and assessed risk of bias using the Cochrane ROB2 and ROBIN-I. The overall strength of evidence was rated using the GRADE guidelines. Due to the heterogeneity of study methodologies a narrative synthesis was employed. Twenty studies were included in the review: fifteen experimental pain and five clinical pain studies, covering multiple motor paradigms. GRADE scores for all outcome measures suggested limited confidence in the reported effect for experimental pain and clinical pain, on motor learning. There was no impact of pain on any of the task performance measures following acquisition except for ‘accuracy’ during a tongue protrusion visuomotor task and ‘timing of errors’ during a motor adaptation locomotion task. Task performance measures at retention, and activity dependent measures at both acquisition and retention showed conflicting results. This review delivers a detailed synthesis of research studies exploring the impact of pain on motor learning. This is despite the challenges provided by the heterogeneity of motor learning paradigms, outcome measures and pain paradigms employed in these studies. The results highlight important questions for further research with the goal of strengthening the confidence of findings in this area.

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Exploring pain interference with motor skill learning in humans: a protocol for a systematic review

Cited by 2 publications

References 53 publications

Can baseline features predict a reduction in pain and disability following neck-specific exercise in people with chronic non-specific neck pain?: A systematic review and meta-analysis protocol

Can baseline features predict a reduction in pain and disability following neck-specific exercise in people with chronic non-specific neck pain?: A systematic review and meta-analysis protocol

Exploring pain interference with motor skill learning in humans: A systematic review

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