Exploring Pharmacological Mechanisms of Xiang Ju Tablets in the Treatment of Allergic Rhinitis via a Network Pharmacology Approach

Hu, Ke; Duan, Xi; Han, Li zhu; Ju, Hong ye; Wang, Bin; Tang, Zhi; Song, Xiao

doi:10.1155/2019/6272073

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…These results were quite similar to our findings, which may indicate the CHM prescriptions for AR were stable in recent decades, and the results in our study were reliable. On the other hand, some studies focused on single HF, such as Ma-Huang-Fu-Zi-Xi-Xin-Tang [ 74 ] and Xiang Ju tablet [ 75 ], or single SH, such as Aconiti lateralis Radix Praeparata [ 76 ], Flos magnolia, and Centipeda minima [ 77 ]. Overall, even though the molecular pathway databases were KEGG (Kyoto Encyclopedia of Genes and Genomes) in these studies instead of Reactome in our work, anti-inflammation effects have been widely discovered among CHMs used for AR, and IL-6, IL-8, and TNF- α were the common target proteins.…”

Section: Discussionmentioning

confidence: 99%

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

Yang

Lin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background and Purpose. Allergic rhinitis (AR) is a highly prevalent disease, and Chinese herbal medicine (CHM) is commonly used for treating AR. This study aims to demonstrate the CHM network for AR and possible molecular pathways. Materials and Methods. Patients with a primary diagnosis of AR (ICD-9-CM code: 477.9) in 2010 were included, and the National Health Insurance Research Database in Taiwan was used as the data source. Association rule mining and social network analysis were used to establish and explore the CHM network. Possible molecular pathways of the CHM network were summarized and compared with commonly used western medicine (WM) by conducting overrepresentation analysis in the Reactome pathway database. The potential proteins acted by CHMs were obtained from the CHM ingredient-protein databases, including STITCH, TCMSP, TCMID, and TCM@Taiwan. Results. There were 89,148 AR subjects found in 2010, and a total of 33,507 patients ever used CHM. On an average, 5.6 types of CHMs were utilized per prescription. Xin-Yi-Qing-Fei-Tang was used most frequently (25.5% of 222,279 prescriptions), while Xiao-Qing-Long-Tang with Xin-Yi-San was the most commonly prescribed CHM-CHM combination. Up to six distinctive clusters could be found among the CHM network, and core CHMs could be found for AR, such as Xiao-Qing-Long-Tang and Xin-Yi-Qing-Fei-Tang. A total of 140 molecular pathways were covered by the CHM network (2,432 ingredients from 31 kinds of CHMs), while 39 WMs covered 55 pathways. Among pathways responding to the immune system, WM mainly acted on cytokine signaling-related pathways, while CHM mostly acted on neutrophil/macrophage-related innate pathways and dendritic cell-related adaptive immunity pathways. Conclusion. Our study demonstrated and analyzed the CHM network for AR. Core CHM for AR and possible molecular pathways were presented as well, and this information is crucial for researchers to select candidates for CHM-related studies.

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Section: Discussionmentioning

confidence: 99%

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

Yang

Lin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…et Zucc. is a widely used herbal medicine for the treatment of rhinitis and sinusitis for decades of years [29]. Previous studies have revealed that the drug has a high content of polyphenols, ellagitannins, and flavone-related compounds.…”

Section: Bioactive Compound Screening From Fpszmentioning

confidence: 99%

Multi‐target bioactive compound screening from the infructescence of Platycarya strobilacea Sieb. et Zucc. by affinity chromatography using immobilized β₂‐adrenoceptor and muscarinic‐3 acetylcholine receptor as the stationary phase

Zhang

Wang

2023

J of Separation Science

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As a main source for the recognition and identification of lead compounds, traditional Chinese medicine plays a pivotal role in preventing diseases for years. However, screening bioactive compounds from traditional Chinese medicine remains challenging because of the complexity of the systems and the occurrence of the synergic effect of the compounds. The infructescence of Platycarya strobilacea Sieb. et Zucc is prescribed for allergic rhinitis treatment with unknown bioactive compounds and unclear mechanisms. Herein, we immobilized the β 2adrenoceptor and muscarine-3 acetylcholine receptor onto the silica gel surface to prepare the stationary phase in a covalent bond through one step. The feasibility of the columns was investigated by the chromatographic method. Ellagic acid and catechin were identified as the bioactive compounds targeting the receptors.The binding constants of ellagic acid were calculated to be (1.56 ± 0.23)×10 7 M −1 for muscarine-3 acetylcholine receptor and (2.93 ± 0.15)×10 7 M −1 for β 2adrenoceptor by frontal analysis. While catechin can bind with muscarine-3 acetylcholine receptor with an affinity of (3.21 ± 0.05)×10 5 M −1 . Hydrogen bonds and van der Waals' force were the main driving forces for the two compounds with the receptors. The established method provides an alternative for multi-target bioactive compound screening in complex matrices.

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“…[ 21 ] The potential mechanism of Flos magnoliae and Centipeda minima for treating AR was also deciphered on the basis of the pharmacology network. [ 22 ] Lastly, Hu et al [ 23 ] employed network pharmacology to reveal the mechanism underlying the efficacy of Xiang Ju tablets in the treatment of AR.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology

Yang

Deng

et al. 2021

Medicine

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In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR. Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed. We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations. These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.

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Exploring Pharmacological Mechanisms of Xiang Ju Tablets in the Treatment of Allergic Rhinitis via a Network Pharmacology Approach

Cited by 8 publications

References 45 publications

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

Multi‐target bioactive compound screening from the infructescence of Platycarya strobilacea Sieb. et Zucc. by affinity chromatography using immobilized β₂‐adrenoceptor and muscarinic‐3 acetylcholine receptor as the stationary phase

Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology

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Exploring Pharmacological Mechanisms of Xiang Ju Tablets in the Treatment of Allergic Rhinitis via a Network Pharmacology Approach

Cited by 8 publications

References 45 publications

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

Identifying the Chinese Herbal Medicine Network and Core Formula for Allergic Rhinitis on a Real‐World Database

Multi‐target bioactive compound screening from the infructescence of Platycarya strobilacea Sieb. et Zucc. by affinity chromatography using immobilized β2‐adrenoceptor and muscarinic‐3 acetylcholine receptor as the stationary phase

Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology

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Multi‐target bioactive compound screening from the infructescence of Platycarya strobilacea Sieb. et Zucc. by affinity chromatography using immobilized β₂‐adrenoceptor and muscarinic‐3 acetylcholine receptor as the stationary phase