Exploring polymorphisms and their effects on reproductive traits of the <i>INHA</i> and <i>INHβA</i> genes in three goat breeds

Hou, Jinxing; An, Xiaopeng; Li, Guang; Wang, Yana; Song, Yuxuan; Cao, Binyun

doi:10.1111/j.1740-0929.2011.00968.x

Cited by 18 publications

(15 citation statements)

References 35 publications

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“…Overall, the highest coverage by ROH was observed on chromosome 1, 2, 6 respectively. Gene INHA, located on chromosome 2, was reported as a candidate gene for litter size in goats [24]. The PPP1R36 and Heat Shock Protein A2 (HSPA2) (CHI10, 26.402-26.719 Mb) identi ed in this communal indigenous goats are involved in heat stress response and in other studies, HSPA2, DNAJC24, and DNAJC13 are associated with the heat shock family of genes [55] .…”

Section: Discussionmentioning

confidence: 76%

Conservation Status and Historical Relatedness of South African Communal Indigenous Goat Populations Using Genome-Wide Snp Marker

Chokoe¹,

Hadebe

Muchadeyi

et al. 2020

Preprint

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Background: Indigenous goats forms the majority of populations in smallholder; low input, low output production systems and are considered an important genetic resource due to their adaptability to different production environments and support communal farming. Effective population size (Ne), inbreeding levels, and the runs of homozygosity (ROHs) are effective tools for exploring the genetic diversity and understanding the demographic history in efforts to support breeding strategies to use and conserve genetic resources. Results: Across populations, the current Ne of Gauteng was the lowest at 371 animals, while the historical Ne across populations suggests that the ancestor Ne has decreased by 53.86%, 44.58%, 42.16% and 41.16% in Free State (FS), North West (NW), Limpopo (LP) and Gauteng (GP), respectively, over the last 971 generations. Genomic inbreeding levels related to ancient kinship (FROH >5Mb) was highest in FS (0.08±0.09) and lowest for Eastern Cape (EC) (0.02±0.02). A total of 871 ROH island regions which include important environmental adaptation and hermo-tolerance genes such as IL10RB, IL23A, FGF9, IGF1, EGR1, MTOR and MAPK3 were identified (occurring in over 20% of the samples) in FS (n = 37), GP (n = 42), NW (n = 2) populations only. The mean length of ROH across populations was 7.76Mb and ranged from 1.61Mb KwaZulu-Natal (KZN) to 98.05Mb (GP and NW). Distribution of ROH according to their size showed that the majority (n = 1949) of the detected ROH were >5Mb in length than the other categories. Assuming two hypothetical ancestral populations, the population from KZN and LP are revealed, supporting PC 1. The genomes of KZN and LP shared an origin but have substantial admixture from the EC and NW populations.Conclusions: These findings indicated a greater negative impact of inbreeding in recent times which is important for planning conservation strategies. It was revealed that the occurrence of high Ne and autozygosity varied largely across breeds in communal indigenous goat populations at different recent and ancient events when a genome-wide SNP marker was used.

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Section: Discussionmentioning

confidence: 76%

Conservation Status and Historical Relatedness of South African Communal Indigenous Goat Populations Using Genome-Wide Snp Marker

Chokoe¹,

Hadebe

Muchadeyi

et al. 2020

Preprint

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“…Chu et al (2007) identified 21 new SNPs of INHβA that significantly influenced litter size in Small Tail Han sheep. Furthermore, Hou et al (2012) identified a synonymous mutation, C936T, of INHβA in three goat breeds, but a functional analysis revealed that this mutation had no effects on its biological function and was not associated with litter size. To date, no significant association of INHβA polymorphisms with female reproductive traits have been identified in bovines.…”

Section: Discussionmentioning

confidence: 99%

“…Chu et al (2007) identified 21 single nucleotide polymorphisms (SNPs) of INHβA, which significantly influenced litter size in Small Tail Han sheep. Hou et al (2012) detected one SNP, C936T, of INHβA in Xinong Saanen, Guanzhong, and Boer goats, but did not show statistically significant associations with litter size. To date, no significant association of INHβA polymorphisms with female reproductive traits has been revealed in bovines.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of the inhibin βA gene and its relationship with superovulation traits in Chinese Holstein cows

Chen

Yang

2014

Genet. Mol. Res.

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ABSTRACT. Inhibin is a major regulator of secretion of folliclestimulating hormone, which is involved in follicular development and regulation of steroidogenesis in females. The objectives of this study were to detect polymorphisms of the bovine inhibin beta-A subunit (INHβA) gene and to evaluate its associations with superovulatory responses in 171 Chinese Holstein cows treated for superovulation. Polymerase chain reaction-restricted fragment length polymorphism revealed a C>T transition determining the StyI polymorphism at position 7639 in intron I of the bovine INHβA gene, and three genotypes (CC, CT, and TT) were detected. The frequencies of the three genotypes showed a tendency for CT > TT > CC, and this polymorphism was in Hardy-Weinberg equilibrium. Statistical analysis revealed no significant differences of least square means for superovulation traits among the three genotypes (P > 0.05). These results demonstrate, for the first time,

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“…In goat, the studies worked to identify the key genes that involved in the regulation of ovulation rate and kidding rate by transcriptome sequencing of goat ovaries, and the signaling pathways that affected ovulation and fertility [1,4,[19][20][21][22][23][24][25]. The study on litter size of goats showed that PDGFRB, MARCH1, KDM6A, CSN1S1, SIRT3, KITLG, GHR, ATBF1, INHA, GNRH1 and GDF9 might be candidate genes for goat reproductive traits [22,[26][27][28][29][30][31][32][33][34][35]. Growth hormone (GH) and members of the insulin-like growth factors (IGF-I and IGF-II) family system may play a key role in the follicular development and atresia [2,36], and the genes FER1L4 and SRD5A2 may be associated with the high fecundity of goats [37].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of mRNAs and miRNAs in the Ovarian Follicles of Uniparous and Multiple Goats at Estrus Phase

Zou

Zhao

et al. 2019

Preprint

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Background Fertility is an important economic trait in production of meat goat, and follicular development plays an important role in fertility. Despite many mRNAs and microRNAs (miRNAs) have been found in playing critical roles in ovarian biological processes, the interactions between mRNAs and miRNAs in follicular development is not yet completely understood. In addition, less attention has been given to the single follicle (dominant or atretic follicle) in goat. The study was aimed to identify mRNAs, miRNAs and signaling pathways as well as their interaction networks in the ovarian follicles (large follicles and small follicles) of multiple and uniparous goats (Chuanzhong Black Goats) at estrus phase by using a deep RNA-sequencing (RNA-seq) method.Results The result showed that there were more large follicles in multiple than in uniparous goats ( P <0.05), while no difference was observed in small follicles between them ( P >0.05). For the small follicles of multiple and uniparous goats at estrus phase, 289 differentially expressed mRNAs (DEmRNAs) and 16 DEmiRNAs were identified; and for the large follicles, 195 DEmRNAs and 7 DEmiRNAs were identified. Ovarian steroidogenesis and steroid hormone biosynthesis were significantly enriched in small follicles, while ABC transporters and steroid hormone biosynthesis in large follicles. The results of qRT-PCR were generally consistent with the RNA-seq data. The mRNA-miRNA interaction network showed that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b) and PTGFR (miR-182, miR-122) might be related to fertility, but need further verification.Conclusion This study provides the first identification of the DEmRNAs and DEmiRNAs as well as their interactions in the follicles of multiple and uniparous goats at estrus phase by using RNA-seq technology. These analyses provide new clues to uncover molecular mechanisms and signaling networks of goat reproduction which could be potentially used to increase ovulation rate and kidding rate in goat.

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Exploring polymorphisms and their effects on reproductive traits of the INHA and INHβA genes in three goat breeds

Cited by 18 publications

References 35 publications

Conservation Status and Historical Relatedness of South African Communal Indigenous Goat Populations Using Genome-Wide Snp Marker

Conservation Status and Historical Relatedness of South African Communal Indigenous Goat Populations Using Genome-Wide Snp Marker

Polymorphism of the inhibin βA gene and its relationship with superovulation traits in Chinese Holstein cows

Comprehensive Analysis of mRNAs and miRNAs in the Ovarian Follicles of Uniparous and Multiple Goats at Estrus Phase

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