Exploring potential biomarkers of coronary heart disease treated by Jing Zhi Guan Xin Pian using high-throughput metabolomics

Abstract

Coronary heart disease (CHD) is a relatively complex disease characterized by narrowing of the arterial lumen and reduction of blood flow to the heart.

Exploring the pharmacological effects and potential targets of paeoniflorin on the endometriosis of cold coagulation and blood stasis model rats by ultra-performance liquid chromatography tandem mass spectrometry with a pattern recognition approach

“…Biomarkers have become an integral part of the research on diseases. [54][55][56][57][58][59] In this study, it was found that PF regulated 10 biomarkers by the metabolic pathways of phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, and tryptophan metabolism, to achieve a certain therapeutic effect. Although the systematic metabolic analysis was used in our study, we can integrate the physiological indicators and pathological observations to improve this study.…”

Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry

“…[54][55][56][57][58][59] Liquid chromatography-mass spectrometry (LC-MS) is widely used in metabolic analysis. [60][61][62][63][64][65][66][67][68][69][70][71] It can monitor small molecule metabolites changes in biological samples. [72][73][74][75][76][77][78][79][80][81][82][83] In this study, we used the untargeted metabolomics technology to discover the metabolic pathways and biomarkers to reveal the potential biological mechanism of syringin on the hepatitis B virus.…”

Ultra-performance liquid chromatography-mass spectrometry-based metabolomics reveals Huangqiliuyi decoction attenuates abnormal metabolism as a novel therapeutic opportunity for type 2 diabetes

“…Mass spectrometry-based metabolomics has enabled the discovery of many biomarkers and provides insight into pathogenesis, disease diagnosis, 56-75 treatment prognosis, [76][77][78][79][80] and monitoring testing. [81][82][83][84][85][86][87] Some researchers have found that amino acids are the nal metabolites of proteins. The amino acid spectrum of diabetic patients undergoes characteristic changes.…”