Exploring probiotic use in a regional cystic fibrosis consortium

González, Karla Sofia Gutiérrez; Zuckerman, Jonathan B.; Sears, Edmund H.; Prato, B. Stephen; Guill, Margaret F.; Craig, Wendy Y.; Milliard, C.; Parker, Emily C; Lever, Thomas; Griffin, Mary M.; Leclair, Laurie W

doi:10.1016/j.jcf.2017.07.018

Cited by 3 publications

(2 citation statements)

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“…A modified fivephase approach was used for identifying, analysing and reporting themes in text data. 28,29 Coding of data and identification of themes were reviewed by a second researcher and any discrepancies were resolved by a third researcher.…”

Section: Discussionmentioning

confidence: 99%

“…These were designed to complement and add depth to quantitative data, as well as to provide further insight into probiotic use from the participants perspective. A modified five‐phase approach was used for identifying, analysing and reporting themes in text data 28,29 . Coding of data and identification of themes were reviewed by a second researcher and any discrepancies were resolved by a third researcher.…”

Section: Methodsmentioning

confidence: 99%

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Probiotic use in adults with cystic fibrosis is common and influenced by gastrointestinal health needs: A cross‐sectional survey study

Anderson

Tierney

Miles

et al. 2022

J Human Nutrition Diet

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Background: Cystic fibrosis (CF) primarily affects the lung, however, gastrointestinal disorders and symptoms, including dysbiosis, also impact on morbidity and quality of life. There is interest in strategies to modulate the gastrointestinal microbiota, including probiotics, although the evidence remains inadequate to guide practice, and information on use is limited. The present study aimed to characterise probiotic use, beliefs and experiences of adults with CF. Methods: A cross-sectional questionnaire study was conducted in adults with CF (n = 205) and a general population Control group (n = 158), recruited from Victoria, Australia. Participants were classified as probiotic 'Ever Users' or 'Never Users'. Outcomes included self-reported probiotic use and factors associated with probiotic use, which were analysed using logistic regression analysis. Open-ended questionnaire responses were thematically analysed. Results: In total, 70% of adults with CF had ever used probiotics (supplements and/or foods), comparable to Controls (80%) (p = 0.03). Key reasons for CF probiotic use were gastrointestinal-and antibiotic-related (75%). Most CF Ever Users (73%) did not discuss probiotic use with CF clinicians and 33% were uncertain if probiotics had been helpful. Female gender (odds ratio [OR] = 2.82; 95% confidence interval [CI] = 1.36-5.87; p = 0.005), universitylevel education (OR = 2.73; 95% CI = 1.24-6.01; p = 0.01) and bloating on antibiotics (OR = 2.14; 95% CI = 1.04-4.40; p = 0.04) were independently associated with probiotic use in CF; as was female gender in Controls (OR = 2.84; 95% CI = 1.20-6.71; p = 0.02). Conclusions: Probiotics were used by adults with CF for gastrointestinal-and antibiotic-related reasons often without informing clinicians and despite uncertainty about perceived helpfulness. Further research investigating gastrointestinal outcomes of probiotics will inform practice recommendations guiding their use in CF and other chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Probiotic use in adults with cystic fibrosis is common and influenced by gastrointestinal health needs: A cross‐sectional survey study

Anderson

Tierney

Miles

et al. 2022

J Human Nutrition Diet

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ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis

Wilschanski,

Munck,

Carrion

et al. 2024

Clinical Nutrition

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Probiotic knowledge of adults with cystic fibrosis is limited but is associated with probiotic use: A cross-sectional survey study

et al. 2022

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Background: Probiotics are used by people with cystic fibrosis (CF) and other chronic diseases to manage gastrointestinal symptoms. Aim: To describe probiotic knowledge; its relationship with probiotic use, probiotic information sources and factors influencing choice in adults with CF and a general population control group. Methods: A cross-sectional questionnaire study was conducted in adults with CF (n = 205) and Controls (n = 158). Probiotic knowledge was compared between CF and Controls using a knowledge score (maximum 5) based on predefined criteria: (1a) bacteria/microorganism; (1b) live; (2a) administered; (2b) adequate dose and (3) health benefit, using independent samples t-test. Two-way analysis of variance explored knowledge scores between CF and Control and between Ever User and Never User groups. Chi-square and Fisher's exact tests compared knowledge criterion, probiotic sources and influences on probiotic choice between groups. Thematic analysis of open-text responses explored probiotic-related knowledge and influences on probiotic decision making. Results: Knowledge scores (mean ± SD) did not differ between CF (1.70 ± 1.12) and Controls (1.89 ± 0.99), p = 0.13. Probiotic use was associated with knowledge score ( p < 0.001). More CF Ever Users than Never Users correctly identified criteria 1a (65% vs. 38%), 1b (16% vs. 0%), 2a (45% vs. 22%) and 3 (73% vs. 42%) (all p < 0.005). CF participants considered ‘dairy yoghurt’ (69%), ‘live cultures’ (64%) and ‘fermented foods’ (37%) as ‘all/mostly’ probiotic sources. The internet was the commonest source of probiotic-related information. Conclusion: Probiotic knowledge and use were associated in adults with CF. Understanding of probiotic characteristics and sources were limited. Education is needed to help guide patient probiotic decision making.

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Exploring probiotic use in a regional cystic fibrosis consortium

Cited by 3 publications

References 3 publications

Probiotic use in adults with cystic fibrosis is common and influenced by gastrointestinal health needs: A cross‐sectional survey study

Probiotic use in adults with cystic fibrosis is common and influenced by gastrointestinal health needs: A cross‐sectional survey study

ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis

Probiotic knowledge of adults with cystic fibrosis is limited but is associated with probiotic use: A cross-sectional survey study

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