Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in management of diabetes mellitus

Behl, Tapan; Gupta, Amit; Sehgal, Aayush; Albarrati, Ali; Albratty, Mohammed; Meraya, Abdulkarim M.; Najmi, Asim; Bhatia, Saurabh; Bungău, Simona

doi:10.1016/j.biopha.2022.113405

Cited by 22 publications

(11 citation statements)

References 118 publications

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“…The term "Diabetes Mellitus" (DM) refers to a range of physiological dysfunctions that are directly caused by insulin resistance, insufficient insulin secretion, or excessive glycogen secretion and are characterized by hyperglycemia. [1][2] Due to changes in people's lifestyles, which result in less physical activity and more obesity, the main causes of diabetic diseases, diabetes is expanding in scope. [3,4] There are two classifications of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Investigation of The Effect of Acylthiourea Derivatives on Diabetes‐Associated Enzymes

et al. 2022

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One of the most prevalent chronic metabolic disorders, diabetes mellitus, is defined by chronic hyperglycemia and the emergence of microvascular and macrovascular pathology unique to diabetes. Several diabetes problems are primarily caused by persistent hyperglycemia. In this study, aldose reductase (AR) and sorbitol dehydrogenase (SDH) enzymes were purified using chromatographic techniques from sheep kidneys and α-glycosidase purchased commercially. The inhibitory effect of seven acylthiourea compounds on the activity of these enzymes associated with diabetes was investigated. As a result of the studies, the acyl thioureas showed an inhibition effect at the micromolar level on the activity of studied enzymes. The most active compound dimethyl 1-((4-methoxybenzoyl)carbamothioyl)-5,5-diphenylpyrrolidine-2,4-dicarboxylate (2 c) had an excellent selectivity on AR with K i : 0.200 � 0.024 μM and dimethyl 1-((2,4-dichlorobenzoyl)carbamothioyl)-5,5-diphenylpyrrolidine-2,4-dicarboxylate (2 g) on SDH and αglycosidase with K i : 0.114 � 0.01 μM and K i : 055 � 0.01 μM, respectively. The findings suggest that our study will contribute to the development of innovative and/or alternative treatment strategies in the treatment of diabetes in the future since acylthiourea compounds have an effective inhibition capacity on critical enzymes associated with diabetes.

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Section: Introductionmentioning

confidence: 99%

Investigation of The Effect of Acylthiourea Derivatives on Diabetes‐Associated Enzymes

et al. 2022

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“…Attention is drawn to the imperative of standardizing this bee-derived product while implementing rigorous quality control measures. Certain researchers have already taken steps in this direction, particularly in relation to Brazilian green propolis [ 315 ] and propolis of the poplar variety [ 316 , 317 , 318 ]. It is only when such standardization is achieved that this natural product can truly serve as a viable adjunctive therapy with internationally recognized quality control standards.…”

Section: Shortcomings and Perspectivesmentioning

confidence: 99%

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Scorza,

Goncalves,

Finsterer

et al. 2024

Cells

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Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis’ properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis’ role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.

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“…Among these, PTP1B stands out, which also exerts an inhibition on leptin signaling. Drugs targeting PTP1B have given promising results in T2DM animal models [ 208 ], but due to limited information on their safety, it has not been possible to use them in patients. There is a close relationship between obesity and leptin resistance, which may precede or co-occur with T2DM.…”

Section: Functionality Of Leptin and Its Involvement In Pathologymentioning

confidence: 99%

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

Casado

Collado-Pérez

Frago

et al. 2023

IJMS

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Excess body weight is frequently associated with low-grade inflammation. Evidence indicates a relationship between obesity and cancer, as well as with other diseases, such as diabetes and non-alcoholic fatty liver disease, in which inflammation and the actions of various adipokines play a role in the pathological mechanisms involved in these disorders. Leptin is mainly produced by adipose tissue in proportion to fat stores, but it is also synthesized in other organs, where leptin receptors are expressed. This hormone performs numerous actions in the brain, mainly related to the control of energy homeostasis. It is also involved in neurogenesis and neuroprotection, and central leptin resistance is related to some neurological disorders, e.g., Parkinson’s and Alzheimer’s diseases. In peripheral tissues, leptin is implicated in the regulation of metabolism, as well as of bone density and muscle mass. All these actions can be affected by changes in leptin levels and the mechanisms associated with resistance to this hormone. This review will present recent advances in the molecular mechanisms of leptin action and their underlying roles in pathological situations, which may be of interest for revealing new approaches for the treatment of diseases where the actions of this adipokine might be compromised.

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Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in management of diabetes mellitus

Cited by 22 publications

References 118 publications

Investigation of The Effect of Acylthiourea Derivatives on Diabetes‐Associated Enzymes

Investigation of The Effect of Acylthiourea Derivatives on Diabetes‐Associated Enzymes

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

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