Exploring public health benefits of Dolichos lablab as a dietary supplement during the COVID-19 outbreak: A computational study

Abstract

The emerging case of coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndromecoronavirus (SARS-CoV-2) virus has become a global health issue. Since there is no available developed vaccine, health-promoting foods play a vital role in maintaining the immune system against the disease. Dolichos lablab (DL), an unutilized highly nutritional legume, has an excellent potential to cope with this pandemic with various health benefit phytochemicals. This study appraised the possibility of phytochemical content from DL to prevent virus infection and hyperinflammation in COVID-19 in silico. DL's phytochemicals from liquid chromatography-high-resolution mass spectrometry analysis were docked with several SARS-CoV-2 proteins, including main protease and HR. Also, NF-κB docking was executed to pursue anti-inflammatory properties. The drug-likeness properties of screened phytochemicals were then evaluated using SwissADME. According to the results, there were 16 phytochemicals with a high affinity to targeted proteins. Among those, five phytochemicals consistently gave a low binding affinity to all targeted proteins. Those five phytochemicals' physicochemical properties, except for rutin and (9cis)-retinal, also coped with small-molecule bioavailability, permeability, and flexibility according to the SwissADME calculations. In conclusion, DL has a high probability of complementing the medical effort as dietary supplementation to modulate the immune system and prevent viral infection.

Nutritional Contents and Bioactive Compounds among Several Variants of <i>Dolichos lablab</i>: Fundamental Facts for Functional Food Development

“…Although other variants may exist, these three are commonly found in several regions in Indonesia, such as East Java (Probolinggo and Madura Island) and West Nusa Tenggara (Purwanti et al 2019b). The previous study reported the bioactivity of bioactive compounds and nutritional values of Lablab beans (Purwanti et al 2021;Purwanti et al 2022). Nevertheless, no report addresses the nutritional differences among the variants of Lablab beans.…”

“…Nevertheless, no report addresses the nutritional differences among the variants of Lablab beans. Lablab beans have numerous bioactivities including antioxidant (Maheshu et al 2013), antidiabetic (Purwanti et al 2022), antivirus (Purwanti et al 2021), antimicrobial (Bai-Ngew et al 2021, and anti-inflammatory properties (An et al 2020). These bioactivities make it a promising and excellent candidate for functional food development.…”