The aim of this research was to analyze the challenges of nurse faculty when teaching culturally and linguistically diverse (CLD) students. BACKGROUND CLD students struggle academically and may need accommodations to be successful. There is a lack of research on challenges faced by faculty when teaching CLD students and faculty perceptions of those challenges. METHOD Data were collected via an online survey and in-person interviews. RESULTS Several challenges were uncovered. The most common challenges were related to language barriers and lack of support in teaching CLD students. CONCLUSION Nursing faculty members have several challenges in teaching CLD nursing students and should receive training to better understand, assess, and instruct their students.