A structural equation model was used to verify both the direct and indirect influences on research and development and innovation capabilities that affect Thai automotive parts enterprises competitive advantage. Thailand’s automotive sector is a major driver of the economy with a multi-thousand network of both domestic and international companies contributing a significant amount to both domestic and Asian economic growth. After peaking in 2013 and reaching the Top 10 automotive nations, there has been a slide backwards. Competition is fierce and the pace of change ever quickening. Therefore, the researchers sought to determine how the automotive parts sector needed to improve in capability, skills and infrastructure to maintain a sustainable competitive advantage. From the structural equation model analysis of 220 regional automotive parts sector managers and use of AMOS software, it was determined that research and development combined with innovation plays key roles in the industry’s profitability and survivability. Additionally, there must be support across a wide sector of the economy, including universities, government agencies and institutions. Once championed as the ‘Detroit of Asia’, Thailand’s recognized success as a global automotive hub is a classic case of a well-executed industrial plan but that lead can potentially slip away without embracing new technologies and innovative thinking.