Exploring risk factors for stuttering development in Parkinson disease after deep brain stimulation

Picillo, Marina; Vincos, Gustavo Barrios; Sammartino, Francesco; Lozano, Andrés M.; Fasano, Alfonso

doi:10.1016/j.parkreldis.2017.02.015

Cited by 18 publications

(4 citation statements)

References 15 publications

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“…This dopamine reduction hypothesis may be consistent with the results from a previous study that provided evidence for a re‐emergence of stuttering in PD . Also, the reduction of levodopa medication dosage following DBS surgery may play a role in the development of post‐DBS stuttering in some IWPD . Perhaps a trial increase in levodopa dosage should be re‐examined in cases of post‐DBS stuttering .…”

Section: Discussionsupporting

confidence: 86%

Effect of Levodopa on Speech Dysfluency in Parkinson's Disease

Adams

Abeyesekera

et al. 2018

Movement Disord Clin Pract

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Objective Objective: To examine the effect of levodopa medication on speech dysfluency in Parkinson's disease. MethodsMethods: Fifty-one individuals with Parkinson's disease (IWPD) read aloud during offand onmedication states. Total speech dysfluencies were calculated from transcriptions of recorded speech samples. ResultsResults: Severity of speech dysfluency was not significantly related to the severity of motor symptoms, duration of disease, levodopa equivalent dosage, or age. When the IWPD were divided into two groups based on dysfluency severity, there was a significant group-by-medication state interaction. There was a significant correlation between the medication-related change in speech dysfluency and the off-medication severity of speech dysfluency measure (r = −0.46). Conclusions Conclusions:The results of this study indicate that levodopa medication can have a significant effect on speech dysfluency. The beneficial levodopa effect appears to be related to the severity of the off-medication speech dysfluency. Results did not provide strong support for the excess dopamine theory of stuttering in IWPD. A dualistic model of the effects of dopamine on speech fluency in PD is proposed.

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Section: Discussionsupporting

confidence: 86%

Effect of Levodopa on Speech Dysfluency in Parkinson's Disease

Adams

Abeyesekera

et al. 2018

Movement Disord Clin Pract

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“…Syllable repetitions are frequent in PD patients, even though assessment may be complicated by concomitant dysarthria (Hertrich et al, 1994). In addition, deep brain stimulation of either suthalamic nucleus or globus pallidus internus may worsen preexisting childhood onset stuttering, or induce the occurrence of stuttering (Picillo et al, 2017). (3) Neurophysiologically, the balance between inhibitory and excitatory motor intracortical interneurons is tilted in basal ganglia disorders such as Parkinson's disease or dystonia, with less active intracortical inhibitory circuits (Ridding et al, 1995a,b).…”

Section: Introductionmentioning

confidence: 99%

Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter

Liman

Gudenberg²,

Baehr

et al. 2021

Front. Hum. Neurosci.

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PurposeChildhood onset speech fluency disorder (stuttering) is possibly related to dopaminergic dysfunction. Mesencephalic hyperechogenicity (ME) detected by transcranial ultrasound (TCS) might be seen as an indirect marker of dopaminergic dysfunction. We here determined whether adults who stutter since childhood (AWS) show ME.MethodsWe performed TCS in ten AWS and ten matched adults who never stuttered. We also assessed motor performance in finger tapping and in the 25 Foot Walking test.ResultsCompared to controls, AWS showed enlarged ME on either side. Finger tapping was slower in AWS. Walking cadence, i.e., the ratio of number of steps by time, tended to be higher in AWS than in control participants.DiscussionThe results demonstrate a motor deficit in AWS linked to dopaminergic dysfunction and extending beyond speech. Since iron deposits evolve in childhood and shrink thereafter, ME might serve as an easily quantifiable biomarker helping to predict the risk of persistency in children who stutter.

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“…Recent studies further demonstrated that DBS is a therapeutic option even in the early stages of PD 6 . However, DBS may exert adverse effects on non‐motor PD symptoms, such as impulsivity, 7 depression, 8 speech fluency, and cognition 9,10 . The mechanisms underlying the DBS‐induced amelioration of PD motor dysfunction and the effects of the combination of DBS with L‐DOPA on the neuronal network are elusive.…”

Section: Introductionmentioning

confidence: 99%

Effect of deep brain stimulation on brain network and white matter integrity in Parkinson's disease

Huang

Chen²,

Wu³

et al. 2021

CNS Neurosci Ther

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Aims The effects of subthalamic nucleus (STN)‐deep brain stimulation (DBS) on brain topological metrics, functional connectivity (FC), and white matter integrity were studied in levodopa‐treated Parkinson’s disease (PD) patients before and after DBS. Methods Clinical assessment, resting‐state functional MRI (rs‐fMRI), and diffusion tensor imaging (DTI) were performed pre‐ and post‐DBS in 15 PD patients, using a within‐subject design. The rs‐fMRI identified brain network topological metric and FC changes using graph‐theory‐ and seed‐based methods. White matter integrity was determined by DTI and tract‐based spatial statistics. Results Unified Parkinson's Disease Rating Scale III (UPDRS‐ III) scores were significantly improved by 35.3% (p < 0.01) after DBS in PD patients, compared with pre‐DBS patients without medication. Post‐DBS PD patients showed a significant decrease in the graph‐theory‐based degree and cost in the middle temporal gyrus and temporo‐occipital part‐Right. Changes in FC were seen in four brain regions, and a decrease in white matter integrity was seen in the left anterior corona radiata. The topological metrics changes were correlated with Beck Depression Inventory II (BDI‐II) and the FC changes with UPDRS‐III scores. Conclusion STN‐DBS modulated graph‐theoretical metrics, FC, and white matter integrity. Brain connectivity changes observed with multi‐modal imaging were also associated with postoperative clinical improvement. These findings suggest that the effects of STN‐DBS are caused by brain network alterations.

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Exploring risk factors for stuttering development in Parkinson disease after deep brain stimulation

Cited by 18 publications

References 15 publications

Effect of Levodopa on Speech Dysfluency in Parkinson's Disease

Effect of Levodopa on Speech Dysfluency in Parkinson's Disease

Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter

Effect of deep brain stimulation on brain network and white matter integrity in Parkinson's disease

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