Exploring <scp>microRNAs</scp> in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential

Nie, Xuqiang; Zhao, Jiufeng; Ling, Hua; Deng, Youcai; Li, Xiaohui; He, Yuqi

doi:10.1111/bph.15139

Cited by 21 publications

(11 citation statements)

References 153 publications

(198 reference statements)

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“…The chronic wound formation process is also regulated epigenetically by miRNAs controlling inflammatory responses via the modulation of signaling pathways. Wnt/β-catenin, NF-κB, PI3K/Akt/mTOR, TGF-β/Smad and VEGF pathways are regulated by miRNAs during chronic wound healing [104]. Immune system in chronic wound healing.…”

Section: Chronic Wound Healingmentioning

confidence: 99%

Immunology of Acute and Chronic Wound Healing

et al. 2021

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Skin wounds greatly affect the global healthcare system, creating a substantial burden on the economy and society. Moreover, the situation is exacerbated by low healing rates, which in fact are overestimated in reports. Cutaneous wounds are generally classified into acute and chronic. The immune response plays an important role during acute wound healing. The activation of immune cells and factors initiate the inflammatory process, facilitate wound cleansing and promote subsequent tissue healing. However, dysregulation of the immune system during the wound healing process leads to persistent inflammation and delayed healing, which ultimately result in chronic wounds. The microenvironment of a chronic wound is characterized by high quantities of pro-inflammatory macrophages, overexpression of inflammatory mediators such as TNF-α and IL-1β, increased activity of matrix metalloproteinases and abundance of reactive oxygen species. Moreover, chronic wounds are frequently complicated by bacterial biofilms, which perpetuate the inflammatory phase. Continuous inflammation and microbial biofilms make it very difficult for the chronic wounds to heal. In this review, we discuss the role of innate and adaptive immunity in the pathogenesis of acute and chronic wounds. Furthermore, we review the latest immunomodulatory therapeutic strategies, including modifying macrophage phenotype, regulating miRNA expression and targeting pro- and anti-inflammatory factors to improve wound healing.

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Section: Chronic Wound Healingmentioning

confidence: 99%

Immunology of Acute and Chronic Wound Healing

et al. 2021

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“…Previous studies have confirmed that ncRNAs are differentially expressed in patients with diabetes and are closely related to the occurrence and development of the disease. 113,115,116 Lin et al 88 showed that the serum levels of miR-217 in DFU patients was significantly upregulated compared with those of healthy individuals. Moreover, as the Wagner grade increases, the serum miR-217 level gradually increases.…”

Section: The Application Prospects Of Ncrna In Diagnosis and Treatmentmentioning

confidence: 99%

The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Wei

Liu

et al. 2021

Molecular Therapy - Nucleic Acids

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Chronic diabetic wounds affect the quality of life of patients, resulting in significant social and economic burdens on both individuals and the health care system. Although treatment methods for chronic diabetic wounds have been explored, there remains a lack of effective treatment strategies; therefore, alternative strategies must be explored. Recently, the abnormal expression of non-coding RNA in diabetic wounds has received widespread attention since it is an important factor in the development of diabetic wounds. This article reviews the regulatory role of three common non-coding RNAs (microRNA [miRNA], long non-coding RNA [lncRNA], and circular RNA [circRNA]) in diabetic wounds and discusses the diagnosis, treatment potential, and challenges of non-coding RNA in diabetic wounds. This article provides insights into new strategies for diabetic wound diagnosis and treatment at the genetic and molecular levels. ncRNA ncRNA refers to a type of RNA that does not encode protein. In the past, it has been shown to participate in a variety of biological processes and play important transcriptional and post-transcriptional regulatory functions. 18 ncRNAs are divided into two categories based on the length of the RNA chain; lncRNA have lengths greater than 200 nucleotides, and small ncRNAs (snRNA) have lengths less than 200 nucleotides. snRNAs can be subdivided into miRNAs and circRNAs. 19 miRNAs inhibit the expression of target genes by binding to the 3 0 untranslated region (3 0 UTR) of the target mRNA. 20 The miRNA gene is processed and cleaved by RNA polymerase II (Pol II) enzyme and endonuclease Drosha III to produce pre-miRNA, which is

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“…Apoptotic cells release chemotactic signaling molecules such as lysophosphatidylcholine (LPC) to attract macrophages to the site of injury; however, when not adequately cleared, these immune cells produce chronic inflammation [49,50]. Chronic wounds, such as diabetic wounds, have decreased PI3K/AKT activity with excessive endothelial and keratinocyte apoptosis while also displaying impaired clearance of apoptotic debris due to immune system dysregulation [51][52][53][54]. Pressure ulcers show a similar downregulation in PI3K/AKT [28].…”

Section: Cellular Deformation and Apoptosismentioning

confidence: 99%

Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment

Niemiec

Louiselle

Liechty

et al. 2020

IJMS

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Pressure ulcers are preventable, yet highly prevalent, chronic wounds that have significant patient morbidity and high healthcare costs. Like other chronic wounds, they are characterized by impaired wound healing due to dysregulated immune processes. This review will highlight key biochemical pathways in the pathogenesis of pressure injury and how this signaling leads to impaired wound healing. This review is the first to comprehensively describe the current literature on microRNA (miRNA, miR) regulation of pressure ulcer pathophysiology.

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Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential

Cited by 21 publications

References 153 publications

Immunology of Acute and Chronic Wound Healing

Immunology of Acute and Chronic Wound Healing

The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment

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