The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response 2021 Help me understand this report
Exploring Sensitivity to Replicative Stress in BRCA-Deficient Triple Negative Breast Cancer
Abstract: Defective Homologous Recombination repair (HRR) Unrepaired DNA breaksSensitivity to Genotoxic drugs 30-35% of TNBC are BRCA-deficient TNBC and BRCAness Genotoxic chemicals UV IR Exogenous Factors Endogenous Factors DNA replication 3D chromatin structure Free Radicals Replicative stress Blocked DNA replication, and reduced origin firing accumulation of single strand DNA stretches
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