Exploring Sex and Laterality Imbalances in Patients Undergoing Laser Retinopexy

Mahroo, Omar A.; Mitry, Danny; Williamson, Tom H.; Shepherd, Ashley; Charteris, David G.; Hamilton, Robin

doi:10.1001/jamaophthalmol.2015.2731

Cited by 10 publications

(13 citation statements)

References 15 publications

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“…This male and right laterality slight majority is a finding also reported by Mahroo et al. (2015) and in meta‐analysis that explored sex and laterality of RRD (Mitry et al. 2010a; Mitry et al.…”

Section: Discussionsupporting

confidence: 79%

“…We found that we had a slight male and right laterality preponderance in our cohort. This male and right laterality slight majority is a finding also reported by Mahroo et al (2015) and in meta-analysis that explored sex and laterality of RRD (Mitry et al 2010a;Mitry et al 2010b;Mitry et al 2011). The higher male gender has often been attributed to higher rate of trauma, but previous studies have risk adjusted for this in RRD rate and found this trend to persist despite excluding trauma (Mitry et al 2010a;Mitry et al 2010b).…”

Section: Discussionsupporting

confidence: 67%

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Effect of demographics and ethnicity on laser retinopexy in preventing retinal detachment in a tertiary eye hospital in 812 eyes

Moussa

Samia-Aly

Ch'ng

et al. 2021

Acta Ophthalmologica

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Purpose To investigate different baseline characteristics, clinical indications, repeat retinopexy rate, and 6‐month detachment rate of primary laser retinopexy across different ethnicities. Method Retrospective, single‐centre, consecutive comparative study, looking at all patients who had primary laser retinopexy between January 2017 and 2020. Multivariate Cox survival [reporting hazard ratio (HR)] and binary logistic regression (reporting odds ratio) analyses were performed to investigate differences between ethnicities with age, gender, operator level (vitreoretinal or general ophthalmologist) and high myopia status (≤−6.0 Dioptres) as covariates. Results We report on 812 patients in three ethnicities: Black [69 (8.5%)], South Asian [SA, 156 (19.2%)] and White [587 (72.3%)] with overall 6‐month detachment rate of 31 (3.8%). Rate for subsequent retinopexies was Black: 12 (17.4%), SA: 15 (9.6%) and White: 131 (22.3%), p = 0.002. Multivariate Cox survival regression analysis found no difference in detachment rate between ethnicities. South Asian (SA) had lower repeat retinopexy rate than White patients [HR, 0.40 (95% confidence interval [CI], 0.22–0.71, p = 0.002)]. Multivariate binary logistic regression found that Black and SA patients compared with White, have the following: (i) higher proportion of round holes relative to horseshoe tears [OR, 2.31 (95% CI, 1.19–4.49, p = 0.014) and OR, 2.06 (95% CI, 1.25–3.40), p = 0.004, respectively] and (ii) higher proportion of high myopia [OR, 2.99 (95% CI, 1.20–7.46, p = 0.019) and OR, 2.35 (95% CI, 1.11–4.96), p = 0.025, respectively]. Ethnic minorities were younger than White patients: SA [43, interquartile range (IQR), 28–61], Black (49, IQR, 35–57) and White (61, IQR, 54–67 years, p < 0.001) and had more indirect and 360 retinopexy compared with slit lamp (p < 0.001). Conclusion We demonstrate a significant difference in baseline characteristics, retinal tear morphology and treatment course between the ethnic groups. Further studies are necessary to investigate the genetic and biological differences that may influence these variations and may help to allow for more targeted health care.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 67%

Effect of demographics and ethnicity on laser retinopexy in preventing retinal detachment in a tertiary eye hospital in 812 eyes

Moussa

Samia-Aly

Ch'ng

et al. 2021

Acta Ophthalmologica

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“…Our series included a relatively high proportion of men (60.2%), which has been previously reported [12,13]. Our series did not include a predilection for a specific side; 53.1% of retinal tears were in left eyes, contrasting with previous reports in which a slight predominance of right eyes was noted [12,13]. Mild VH was encountered in 27% of the eyes, a bridging blood vessel in 9.8%, and SRF in 19.8%.…”

Section: Discussionmentioning

confidence: 64%

Outcomes following Laser Retinopexy for Retinal Tears: A Comparative Study between Trainees and Specialists

2020

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Objective: To compare the outcomes of laser retinopexy for the treatment of retinal tears between residents and specialists, and to identify tear characteristics associated with the risk of progression to retinal detachment (RD). Methods: A retrospective review of 307 eyes treated by laser retinopexy, categorized by the performing physician, either a resident (217 cases) or a specialist (90 cases). Recorded parameters included the number, size, and location of the retinal tears, the presence of bridging vessels, vitreous hemorrhage (VH), or subretinal fluid (SRF), the need for additional laser, progression to RD, and surgery. Results: Additional laser was performed in 42.3% of cases in the resident group and 35.5% in the specialist group (p = 0.26). Progression to RD occurred in 6.9% of cases in the resident group and 5.5% in the specialist group (p = 0.66). The presence of VH and SRF were associated with an increased risk of progression to RD (p < 0.0001 and 0.003, respectively). A higher proportion of cases with SRF were treated by specialists (p = 0.006). Conclusions: Laser retinopexy is safely and effectively performed by residents, with no worse outcomes than procedures performed by specialists. A high rate of additional laser may be needed to achieve RD prophylaxis, and higher-risk cases can be identified at presentation and then referred to specialists.

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“…The authors query whether this was associated with ocular dominance in some way, but this remains unknown. A further retrospective study of laser retinopexies for treating retinal tears also found a higher number in right eyes (Mahroo et al, 2015).…”

Section: Retinal Detachmentmentioning

confidence: 89%

Lateral thinking – Interocular symmetry and asymmetry in neurovascular patterning, in health and disease

Cameron

Megaw

Tatham

et al. 2017

Progress in Retinal and Eye Research

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No biological system or structure is likely to be perfectly symmetrical, or have identical right and left forms. This review explores the evidence for eye and visual pathway asymmetry, in health and in disease, and attempts to provide guidance for those studying the structure and function of the visual system, where recognition of symmetry or asymmetry may be essential. The principal question with regards to asymmetry is not 'are the eyes the same?', for some degree of asymmetry is pervasive, but 'when are they importantly different?'. Knowing if right and left eyes are 'importantly different' could have significant consequences for deciding whether right or left eyes are included in an analysis or for examining the association between a phenotype and ocular parameter. The presence of significant asymmetry would also have important implications for the design of normative databases of retinal and optic nerve metrics. In this review, we highlight not only the universal presence of asymmetry, but provide evidence that some elements of the visual system are inherently more asymmetric than others, pointing to the need for improved normative data to explain sources of asymmetry and their impact on determining associations with genetic, environmental or health-related factors and ultimately in clinical practice.

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Exploring Sex and Laterality Imbalances in Patients Undergoing Laser Retinopexy

Cited by 10 publications

References 15 publications

Effect of demographics and ethnicity on laser retinopexy in preventing retinal detachment in a tertiary eye hospital in 812 eyes

Effect of demographics and ethnicity on laser retinopexy in preventing retinal detachment in a tertiary eye hospital in 812 eyes

Outcomes following Laser Retinopexy for Retinal Tears: A Comparative Study between Trainees and Specialists

Lateral thinking – Interocular symmetry and asymmetry in neurovascular patterning, in health and disease

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