Amid growing concern over the changing climate, environment, and health care, the interconnectivity between cardiovascular diseases, coupled with rapid industrialization, and a variety of environmental factors, has been the focus of recent research. It is necessary to research risk factor extraction techniques that consider individual external factors and predict diseases and conditions. Therefore, we designed a framework to collect and store various domains of data on the causes of cardiovascular disease, and constructed a big data integrated database.A variety of open source databases were integrated and migrated onto distributed storage devices. The integrated database was composed of clinical data on cardiovascular diseases, national health and nutrition examination surveys, statistical geographic information, population and housing censuses, meteorological administration data, and Health Insurance Review and Assessment Service data. The framework was composed of data, speed, analysis, and service layers, all stored on distributed storage devices. Finally, we proposed a framework for a cardiovascular disease prediction system based on lambda architecture to solve the problems associated with the real-time analyses of big data. This system can be used to help predict and diagnose illnesses, such as cardiovascular diseases.