Exploring susceptibility and therapeutic targets for kidney stones through proteome-wide Mendelian randomization
Qinhong Jiang,
Xiaozhe Su,
Wenbiao Liao
et al.
Abstract:Given the high recurrence rate of kidney stones, surgical lithotripsy and stone removal are not the ultimate treatments for kidney stones. There’s an urgent need to explore the genetic mechanisms behind the susceptibility to kidney stones and to identify potential targets for prevention, to reduce the renal damage caused by recurrent stone formation. In this study, we screened 4548 circulating proteins using proteome-wide Mendelian Randomization (MR) to find proteins with a causal relationship to kidney stone … Show more
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