Exploring the antibiofilm effects on
            <i>Escherichia coli</i>
            biofilm associated with colon cancer and anticancer activities on HCT116 cell line of bee products

Akkoyunlu, Ayşegül; Dülger, Görkem

doi:10.1080/08927014.2024.2338106

Biofouling

2024

DOI: 10.1080/08927014.2024.2338106

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Exploring the antibiofilm effects on Escherichia coli biofilm associated with colon cancer and anticancer activities on HCT116 cell line of bee products

Ayşegül Akkoyunlu,

Görkem Dülger

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2024

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Cited by 2 publications

References 49 publications

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Antioxidant, antimicrobial, antiviral, and antiproliferative properties of Turkish propolis sample

Cora,

Üreyen Esertaş,

Kara

et al. 2024

Eur Food Res Technol

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Antioxidant, antimicrobial, antiviral, and antiproliferative properties of Turkish propolis sample

Cora,

Üreyen Esertaş,

Kara

et al. 2024

Eur Food Res Technol

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Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil

Ilie,

Spoiala,

Chircov

et al. 2024

Antioxidants

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The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs’ surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70–75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy.

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Exploring the antibiofilm effects on Escherichia coli biofilm associated with colon cancer and anticancer activities on HCT116 cell line of bee products

Cited by 2 publications

References 49 publications

Antioxidant, antimicrobial, antiviral, and antiproliferative properties of Turkish propolis sample

Antioxidant, antimicrobial, antiviral, and antiproliferative properties of Turkish propolis sample

Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil

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