Exploring the Antimicrobial Effects of Cervical Mucus in Pregnants and Its Relationship with the Course of Pregnancy

Abstract

A AB BS S TTR RA AC CT T O Ob bj je ec ct ti iv ve e: : To in ves ti ga te whet her the cer vi cal mu cus in preg nants has an ti mic ro bi al activity in vit ro and to de ter mi ne its re la ti ons hip with prog no sis of preg nancy. M Ma at te er ri ia al l a an nd d M Me et t h ho od ds s: : Cervi cal mu cus samp les we re col lec ted from 50 wo men with sing le preg nancy du ring the first tri mes ter. Ste ri li zed Wart man pa pers we re so a ked in to mu cus samp les and dri ed un der ste ri le con di ti ons. Cul turing was per for med by disk dif fu si on met hod which uses Mil ler Hin ton me di um and Mac-Far land 0.5 so lu ti on pre pa red with Staph ylo coc cus au re us, Esc he ric hi a co li, Kleb si el la pne u mo ni a and Can di da albi cans. Po si ti ve or ne ga ti ve zo nes we re de ter mi ned by me a su ring the di a me ters of in hi bi ti on zo nes occur red fol lo wing 18 ho urs in cu ba ti on pe ri od. Prog no sis of preg nants with or wit ho ut an ti mic ro bi al ef fect of cer vi cal mu cus we re com pa red. R Re e s su ul lt ts s: : In 28 ca ses, it was de mons tra ted that cer vi cal mu cus had an ti mic ro bi al ef fects. Du ring the fol low-up pe ri od of 27 preg nants, 22 (81.5%) ga ve vi ab le birth in term, 3 (11.1%) had abor tus, and 1 (3.7%) had early mem bra ne rup tu re at 36th we ek of ges ta ti on. In 22 ca ses, cer vi cal mu cus sho wed no an ti mic ro bi al ef fect. 20 of the se fol lo wed-up and 14 (70.0%) parti ci pants ga ve vi ab le birth at term, 3 (15.0%) had abor tus, and 2 (10.0%) had pre term de li very. The re was no sta tis ti cally sig ni fi cant dif fe ren ce bet we en the two gro ups in terms of preg nancy prog no sis. C Co on nc cl lu us si io on n: : Cer vi cal mu cus pre vents in fec ti ons from va gi na to up per ge ni tal or gans not only mec hani cally but al so by func ti o ning as a che mi cal bar ri er. In our study, it is es tab lis hed that presence or absence an ti mic ro bi al ef fect of mu cus do es not ha ve a sig ni fi cant im pact on the prog no sis of preg nancy. We think that stu di es with gre a ter num ber of par ti ci pants may gi ve dif fe rent re sults. K Ke ey y W Wo or rd ds s: : Cer vix mu cus; preg nancy out co me; an ti-in fec ti ve agents; sec re tory le u kocy te pep ti da se in hi bi tor Ö ÖZ ZE ET T A Am ma aç ç: : İn vit ro ola rak ge be ler de ki ser vi kal mu ku sun an ti mik ro bi yal ak ti vi te ye sa hip olup, olma dı ğı nı araş tır mak ve ge be lik prog no zu ile olan iliş ki si ni sap ta mak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Elli adet tekiz ilk tri mes tır ge be den ser vi kal mu kus alın dı. Mu kus lar steri li ze Wart man ka ğıt la rın dan ha zır lan mış disk le re em di ril di ve ste ril şart lar da ku ru tul du. Staph ylo coc cus au re us, Esc he ric hi a co li, Kleb si el la pne u mo ni a ve Can di da al bi cans'la ha zır lan mış Mac-Far land 0.5 so lus yon la rı, Mil ler Hin ton be si yerle ri kul la nı la rak disk dif füz yon yön te mi ile ekim ya pıl dı. On sekiz sa at lik in kü bas yon pe ri y...