Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan

Abstract

Cytotoxicity and haemocompatibility of γ-radiated Hap met the benchmarks according to ISO 10993-5 and ISO 10993-4 standards, respectively. Moreover, extreme antimicrobial (>98%) and moderate (∼34%) antioxidant properties were also exhibited.

Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation

“…Blood compatibility is another essential factor in evaluating the hydrogel toxicity profile for use as a wound dressing. A hemolysis rate lower than 5% is a criterion for excellent blood compatibility; therefore, we evaluate the blood compatibility of F 5 –Pep through a hemolysis test Figure C shows that all F 5 –Pep group treatments were pale yellow, similar to the Pep and the NaCl groups.…”

Calcined chicken eggshell-derived biomimetic nano-hydroxyapatite as a local drug-delivery aid for doxycycline hyclate: characterization, bio-activity, cytotoxicity, antibacterial activity andin vitrorelease study

“…59,60 The bands around ∼470 cm −1 correspond to the O-P-O symmetric bending modes (n 2 ), while the bands in the range of 557 cm −1 to 601 cm −1 correspond to the O-P-O asymmetric bending modes (n 4 ). 21 The structural OH − group of the prepared HAp samples was observed at 632-634 cm −1 and ∼3572 cm −1 . 61 The observed bands at 873 and 1421 cm −1 for HAp100 and 877 cm −1 and 1415 cm −1 for HAp300 are attributed to the CO Fig.…”

“…Duplicate wells were used for each sample, and a similar procedure was done for all the nHAp samples. The cell viability was calculated as follows: 21 Cell viability ¼ number of live cells Total number of cells  100%…”

“…The antibacterial property of HAp is evident from the literature. 21,82,83 Given that our synthesized nHAp samples were found to be nano-structured based on the particle size measurements using the FESEM images, we explored their antibacterial activity, which will be an exciting addition of properties to the bio-material. Fig.…”

“…2,17 Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) has been recognized as a gold standard biomaterial due to its similarity in structure and behavior to human bone. [18][19][20][21][22][23][24][25] In addition, hydroxyapatite (HAp) possesses superb biocompatibility, osteoconductivity, bioactivity, non-toxicity, non-inammatory properties, and excellent stability. 26 HAp has already been investigated for the localized delivery of drugs such as ciprooxacin, 27 amoxicillin, 15 vancomycin, 29 and gentamicin.…”