Exploring the Causal Relationship between Gut Bacteria and DLBCL through Comprehensive Integration of Prior Studies

Abstract

Previous research has revealed a significant association between the gut microbiome and diffuse large B-cell lymphoma (DLBCL). However, the findings of these studies have yet to be entirely consistent. Whether a causal relationship exists between gut bacterial and DLBCL remains elucidated. We performed two-sample mendelian randomization (MR) using genetic data from MiBioGen and DLBCL summary statistics from GWAS. The primary analysis used inverse variance weighted (IVW), the weighted median, MR-Egger regression, and pleiotropic residual sum and outlier tests. Reverse MR checked for reverse causality. Our study identified four bacterial genera can causally increase the risk of DLBCL disease: Ruminococcus torques.id.14377 (OR 0.44; p = 0.006), Ruminococcaceae UCG014.id.11371 (OR 1.69; p = 0.028), Ruminococcaceae UCG002.id.11360 (OR 0.62; p = 0.023), and Eubacterium oxidoreducens.id.11339 (OR 1.80; p = 0.033). In reverse MR analysis, we found no causal effect from DLBCL to gut bacterial. Our investigation offers indications of causal connections between the gut microbiome and the onset of DLBCL.