2023
DOI: 10.1021/acs.biochem.3c00272
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Exploring the Chain Release Mechanism from an Atypical Apicomplexan Polyketide Synthase

Aaron M. Keeler,
Porter E. Petruzziello,
Elizabeth G. Boger
et al.

Abstract: Polyketide synthases (PKSs) are megaenzymes that form chemically diverse polyketides and are found within the genomes of nearly all classes of life. We recently discovered the type I PKS from the apicomplexan parasite Toxoplasma gondii, TgPKS2, which contains a unique putative chain release mechanism that includes ketosynthase (KS) and thioester reductase (TR) domains. Our bioinformatic analysis of the thioester reductase of TgPKS2, TgTR, suggests differences compared to other systems and hints at a possibly c… Show more

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