Exploring the Chemistry of Natural Products and Biological Properties of Mimosa Linnaeus Genus (FABACEAE-MIMOSOIDADE)

Monção, Nayana Bruna Nery; Araújo, Bruno Quirino; Citó, Antônia Maria d as Graças Lopes

doi:10.21577/1984-6835.20190067

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…When analysing the nanoparticles obtained via the process of green synthesis, there is a coincidence with the crude extract, with the compound being quite similar in regards to both retention time (19.477 min, Figure 6C) and UV-Vis spectrum ( Figure 6D; bands 222, 270 and 347 nm). Although this is the first study of the extract of M. albida, several sources describe the presence of flavones and flavonols in Mimosa species, for instance: Apigenin [59], luteolin [60], quercetin and their glycosides [61], thus allowing us to ratify the interpretation of the information obtained by chromatography. It is important to note that quercetin spectrum has bands at different wavelengths than those observed for M. albida extract, with the presence of a flavone being more likely.…”

Section: Phenolic Profilementioning

confidence: 97%

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

et al. 2020

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The search for sensitive and rapid analytical techniques for the determination of natural antioxidants is an area in constant growth due, among other aspects, to the complexity of plant matrices. In this study, silver nanoparticles prepared with the aqueous extract of Mimosa albida leaves were used to assess their polyphenolic content and antioxidant capacity. Silver nanoparticles were characterized by different techniques. As a result, nanoparticles of 6.5 ± 3.1 nm were obtained. The total phenolic content in the extract was 1320.4 ± 17.6 mg of gallic acid equivalents GAE· 100 g−1 and in the nanoparticles 257.3 ± 5.1 mg GAE· 100 g−1. From the phenolic profile analyzed by ultra high-performance liquid chromatography (UPLC) with a diode-array detector (DAD), the presence of apigenin and luteolin in the plant extract is postulated. The antioxidant capacity measured by oxygen radical absorbance capacity ORAC-fluorescein assay was 86917 ± 6287 and 7563 ± 967 µmol ET g−1 in the extract and nanoparticles respectively. Electrochemical analysis by cyclic voltammetry (CV) confirmed the effective reduction capacity of the Mimosa albida leaves extract to reduce Ag ions to AgNPs and differential pulse voltammetry (DPV) suggested the presence of two main reducing agents in the extract. From this study, it was concluded that the aqueous extract of Mimosa albida contains reducing agents capable of synthesizing silver nanoparticles, which can be used in the phytochemical industry.

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Section: Phenolic Profilementioning

confidence: 97%

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

et al. 2020

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“…Para este trabalho, foram selecionados cinco flavonoides da espécie M. pudica, obtidas a partir do estudo químico realizado por Monção et al (2019). As moléculas selecionadas foram os flavonoides quercetina, luteolina, miricetina, ramnetina e quercitrina (Figura 1).…”

Section: Resultsunclassified

“…A realização do estudo de predição in silico de flavonoides ocorrentes em Mimosa pudica, oriundas do estudo químico realizado por Monção et al (2019), mostrou que M. pudica apresenta um elevado potencial químico a ser explorado em estudo in vitro e in vivo para descoberta de moléculas com potenciais atividades biológicas.…”

Section: Conclusãounclassified

“…conforme realizado porOliveira et al (2018), usando a seguinte escala: (I) Inclui os compostos com valores de DL50 ≤ 50 mg/kg (altamente tóxico); (II) Inclui compostos com valores DL50 > 50 mg/kg e < 500 mg/kg (moderadamente tóxico); (III) Inclui compostos com valores > 500 mg/kg e < 5000 mg/kg (baixa toxicidade); (IV) Inclui compostos com DL50 > 5000 mg/kg (praticamente atóxico).Para toxicidade oral aguda, a análise evidenciou que a quercetina e luteolina são classificadas como categoria II, o que inclui compostos com valores de DL50 superiores a 500 mg/kg mas inferiores a 5000 mg/kg, indicando assim uma toxicidade moderada. Enquanto a ramnetina é classificada como categoria III, indicando uma baixa toxicidade.Os resultados obtidos no estudo in silico dos flavonoides quercetina, luteolina e ramnetina ocorrentes em M. pudica e selecionados a partir do estudo deMonção (2019), mostram que essas moléculas são potenciais para testes pré-clínicos (in vitro e in vivo) que objetivem a busca de novas moléculas a serem aplicadas na P&D de novos medicamentos.Considerando as atividades biológicas do flavonoide quercetina, já foram registradas as atividades antioxidante, antimicrobiana e antifúngica(MENDES et al, 2021). O efeito fotoquimioprotetor da quercetina contra alterações moleculares induzidas por raios ultravioletas foi registrado porVincetini (2009).…”

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Flavonoides Isolados Da Mimosa Pudica: Um Estudo Biológico E Farmacológico De Predição in Silico

Monteiro,

Amorim,

Batista

et al. 2024

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O estudo químico de espécies vegetais é importante de suas ações e farmacológicas com o interesse para identificação de novas substâncias bioativas potencialmente viáveis para o desenvolvimento de novos fármacos. Neste contexto, a espécie Mimosa pudica aponta como uma fonte de substâncias bioativas visto a grande variedade de metabólitos secundários que apresenta. O objetivo deste trabalho foi realizar a predição in silico das atividades biológicas e farmacológicas de flavonoides isolados da espécie Mimosa pudica. A predição de atividades biológicas e dos parâmetros farmacológicos foi realizada através das plataformas de estudo in silico Molinspiration cheminformatics, Pass online, admetSAR. O estudo in silico demonstrou que as moléculas quercetina, luteolina e ramnetina apresentaram potencial para várias atividades biológicas, incluindo as atividades antimutagênica, antioxidante e anti-hemorrágica dentre outras. Estas moléculas também apresentaram boas propriedades farmacológicas e bons parâmetros farmacocinéticos e toxicológicos, com exceção da miricetina e quercetrina. Os resultados obtidos são indicativos para a aplicação das quercetina, luteolina e ramnetina em estudos pré-clínicos, o que torna a espécie Mimosa pudica fonte de novos potenciais bioativos disponíveis na flora brasileira.

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3-O-Acyl Triterpenoids and Antileishmanial Effect of the Ethanolic Extract from Mimosa caesalpiniifolia Inflorescences

Araújo

Monção

Oliveira

et al. 2020

CBC

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Background: imosa caesalpiniifolia Benth. (Mimosaceae) is a native plant from Brazilian Caatinga/Cerrado used in traditional medicine. The aim of this work was to investigate the chemical composition and the antileishmanial activity of the inflorescences from M. caesalpiniifolia. Method: The ethanolic extract from M. caesalpiniifolia inflorescences was submitted to fractionation in silica gel chromatography column, and the known structures were elucidated using spectroscopic methods. The antileishmanial activity of the EtOH extract and pure compounds was evaluated against the promastigote forms of Leishmania amazonensis. Results: In this study, the EtOH extract from M. caesalpiniifolia inflorescences (IC50 = 74.52 µg mL-1) and lupeol (IC50 = 15.40 µg mL-1) demonstrated significant inhibition of the growth at 48 h for promastigote forms of L. amazonensis when compared with Glucantime® (IC50 = 1190.21 µg mL-1), a reference drug. Moreover, the cytotoxicity evaluation of EtOH extract of M. caesalpiniifolia inflorescences against murine peritoneal macrophages was also determined. Then, the selectivity index shows that the EtOH extract of M. caesalpiniifolia inflorescences is more toxic to the parasite than mammalian host cells. The chemical characterization of the ethanolic extract from M. caesalpiniifolia inflorescences resulted in the identification of fatty acids and isoprenoids as lupeol acetate, lupeol, β-amyrin, a mixture of steroids and a mixture of fatty acid triterpenyl esters. 3-O-Acyl triterpenoids are being reported for the first time in M. caesalpiniifolia. Conclusion: The EtOH extract of M. caesalpiniifolia inflorescences is a rich source of triterpenoids and a promising natural product against leishmaniasis.

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Exploring the Chemistry of Natural Products and Biological Properties of Mimosa Linnaeus Genus (FABACEAE-MIMOSOIDADE)

Cited by 3 publications

References 39 publications

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

Flavonoides Isolados Da Mimosa Pudica: Um Estudo Biológico E Farmacológico De Predição in Silico

3-O-Acyl Triterpenoids and Antileishmanial Effect of the Ethanolic Extract from Mimosa caesalpiniifolia Inflorescences

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