2023
DOI: 10.21203/rs.3.rs-3221400/v1
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Exploring the direct or mediating associations between lipids, atherosclerosis, obesity, and intervertebral disc degeneration: a Mendelian randomization study

Abstract: Objective The aim of this study was to investigate whether there is a causal relationship between different lipids and intervertebral disc degeneration, and to verify whether obesity and atherosclerosis mediate the relationship between lipids and intervertebral disc degeneration. Methods Instrumental variables and their associated data were extracted from the corresponding genome-wide association studies. Inverse variance weighted (IVW), Weighted Median Estimator (WME), MR-Egger regression method, Simple mod… Show more

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