Exploring the dynamic behavior of leukocytes with zebrafish

Michael, Cassia; de Oliveira, Sofia

doi:10.1016/j.ceb.2023.102276

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…Furthermore, zebrafish fin injury models, in combination with zebrafish transgenic reporter lines of different cell types and/or chemical mediators of wound inflammation, also allow exploring the role of inflammation in the wound regenerative process and the impact of the immune cell migration machinery on the trajectory of inflammation [20][21][22][23]. Indeed, the alteration of leukocyte dynamics is considered an inflammation parameter [24,25], and tailfin injury in zebrafish represents a powerful physiological setup for qualitative and quantitative live-cell dynamics in inflamed tissues.…”

Section: Zebrafish As Inflammation Modelmentioning

confidence: 99%

Inflammation in Development and Aging: Insights from the Zebrafish Model

Mastrogiovanni,

Martínez-Navarro,

Bowman

et al. 2024

IJMS

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Zebrafish are an emergent animal model to study human diseases due to their significant genetic similarity to humans, swift development, and genetic manipulability. Their utility extends to the exploration of the involvement of inflammation in host defense, immune responses, and tissue regeneration. Additionally, the zebrafish model system facilitates prompt screening of chemical compounds that affect inflammation. This study explored the diverse roles of inflammatory pathways in zebrafish development and aging. Serving as a crucial model, zebrafish provides insights into the intricate interplay of inflammation in both developmental and aging contexts. The evidence presented suggests that the same inflammatory signaling pathways often play instructive or beneficial roles during embryogenesis and are associated with malignancies in adults.

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Section: Zebrafish As Inflammation Modelmentioning

confidence: 99%

Inflammation in Development and Aging: Insights from the Zebrafish Model

Mastrogiovanni,

Martínez-Navarro,

Bowman

et al. 2024

IJMS

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Shape dynamics and migration of branched cells on complex networks

Liu,

Boix-Campos,

Ron

et al. 2024

Preprint

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Migratory and tissue resident cells exhibit highly branched morphologies to perform their function and to adapt to the microenvironment. Immune cells, for example, display transient branched shapes while exploring the surrounding tissues. In another example, to properly irrigate the tissues, blood vessels bifurcate thereby forcing the branching of cells moving on top or within the vessels. In both cases microenvironmental constraints force migrating cells to extend several highly dynamic protrusions. Here, we present a theoretical model for the shape dynamics and migration of cells that simultaneously span several junctions, which we validated by using micropatterns with an hexagonal array, and a neuronal network image analysis pipeline to monitor the macrophages and endothelial cell shapes and migration. In our model we describe how the actin retrograde flow controls branch extension, retraction and global cell polarization. We relate the noise in this flow to the residency times and trapping of the cell at the junctions of the network. In addition, we found that macrophages and endothelial cells display very different migration regimes on the network, with macrophages moving faster and having larger changes in cell length in comparison to endothelial cells. These results expose how cellular shapes and migration are intricately coupled inside complex geometries.

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Subverting Attachment to Prevent Attacking: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion

Mastrogiovanni,

Donnadieu,

Pathak

et al. 2024

Biology

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Cell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions with the extracellular matrix, and the establishment of effector programs. Proper immune control of cancer strongly depends on all these events occurring in a highly accurate spatiotemporal sequence. In response to cancer-associated inflammatory signals, effector immune cells navigating the bloodstream shift from their patrolling exploratory migration mode to establish adhesive interactions with vascular endothelial cells. This interaction enables them to extravasate through the blood vessel walls and access the cancer site. Further adhesive interactions within the tumor microenvironment (TME) are crucial for coordinating their distribution in situ and for mounting an effective anti-tumor immune response. In this review, we examine how alterations of adhesion cues in the tumor context favor tumor escape by affecting effector immune cell infiltration and trafficking within the TME. We discuss the mechanisms by which tumors directly modulate immune cell adhesion and migration patterns to affect anti-tumor immunity and favor tumor evasion. We also explore indirect immune escape mechanisms that involve modifications of TME characteristics, such as vascularization, immunogenicity, and structural topography. Finally, we highlight the significance of these aspects in designing more effective drug treatments and cellular immunotherapies.

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Exploring the dynamic behavior of leukocytes with zebrafish

Cited by 3 publications

References 68 publications

Inflammation in Development and Aging: Insights from the Zebrafish Model

Inflammation in Development and Aging: Insights from the Zebrafish Model

Shape dynamics and migration of branched cells on complex networks

Subverting Attachment to Prevent Attacking: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion

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