Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study

Dzator, Jemima S.A.; Coupland, Kirsten G.; Howe, Peter R.C.

doi:10.1016/j.ibneur.2023.10.005

Cited by 1 publication

(2 citation statements)

References 27 publications

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“…Furthermore, Tietjen et al reported that migraineurs (particularly premenopausal migraineurs) have endothelial dysfunction, as evidenced by elevated concentrations of inflammatory markers such as C-reactive protein and lower nitrate and nitrite levels compared to controls; this may reflect the involvement of cerebrovascular dysfunction in the pathophysiology of hormonal migraine [6]. Building on these findings, we previously investigated whether supplementing the diet with resveratrol (a phytoestrogen with vasoactive properties) for three months could improve cerebrovascular function in hormonal migraineurs [7,8]. We reported some modest alterations in cerebrovascular function following resveratrol supplementation that might have resulted from altered expression of endothelial genes of interest in hormonal migraineurs, but this remains to be directly examined [7].…”

Section: Introductionmentioning

confidence: 94%

“…Building on these findings, we previously investigated whether supplementing the diet with resveratrol (a phytoestrogen with vasoactive properties) for three months could improve cerebrovascular function in hormonal migraineurs [7,8]. We reported some modest alterations in cerebrovascular function following resveratrol supplementation that might have resulted from altered expression of endothelial genes of interest in hormonal migraineurs, but this remains to be directly examined [7].…”

Section: Introductionmentioning

confidence: 99%

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Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine

Dzator,

Smith,

Coupland

et al. 2024

IJMS

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There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of genes related to endothelial function in venous blood (1) might influence cerebrovascular function, (2) differs between hormonal migraineur and non-migraineur women, and (3) changes following resveratrol supplementation. This study utilised data obtained from 87 women (59 hormonal migraineurs and 28 controls) where RNA from venous blood was used to quantify gene expression and transcranial Doppler ultrasound was used to evaluate cerebrovascular function. Spearman’s correlation analyses were performed between gene expression, cerebrovascular function, and migraine-related disability. We compared the expression of genes associated with endothelial function between migraineurs and non-migraineurs, and between resveratrol and placebo. The expression of several genes related to endothelial function was associated with alterations in cerebrovascular function. Notably, the expression of CALCA was associated with increased neurovascular coupling capacity (p = 0.013), and both CALCA (p = 0.035) and VEGF (p = 0.014) expression were associated with increased cerebral blood flow velocity in the overall study population. Additionally, VCAM1 expression correlated with decreased pulsatility index (a measure of cerebral arterial stiffness) (p = 0.009) and headache impact test-6 scores (p = 0.007) in the migraineurs. No significant differences in gene expression were observed between migraineurs and controls, or between placebo and resveratrol treatments in migraineurs. Thus, altering the expression of genes related to endothelial function may improve cerebrovascular function and decrease migraine-related disability.

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