Exploring the external exposome using wearable passive samplers - The China BAPE study

Koelmel, Jeremy P.; Lin, Elizabeth Z.; Guo, Pengfei; Zhou, Jieqiong; He, Jucong; Chen, Alexander; Gao, Ying; Deng, Fuchang; Dong, Haoran; Liu, Yuanyuan; Cha, Yu‐E; Fang, Jianlong; Beecher, Chris; Shi, Xiaoming; Tang, Song; Pollitt, Krystal J. Godri

doi:10.1016/j.envpol.2020.116228

Cited by 39 publications

(44 citation statements)

References 51 publications

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“…PSD configurations and placement can also be optimized to detect specific routes of exposure. For example, some are designed to only measure airborne exposures by minimizing contact with media other than air, either by encasing sampling material or by placing as a brooch over clothing [61][62][63]. Others, such as wristbands, show promise as an integrated measure of multiple exposure pathways [64].…”

Section: Passive Sampling Devices For External Exposome Profilingmentioning

confidence: 99%

Operationalizing the Exposome Using Passive Silicone Samplers

et al. 2022

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The exposome, which is defined as the cumulative effect of environmental exposures and corresponding biological responses, aims to provide a comprehensive measure for evaluating non-genetic causes of disease. Operationalization of the exposome for environmental health and precision medicine has been limited by the lack of a universal approach for characterizing complex exposures, particularly as they vary temporally and geographically. To overcome these challenges, passive sampling devices (PSDs) provide a key measurement strategy for deep exposome phenotyping, which aims to provide comprehensive chemical assessment using untargeted high-resolution mass spectrometry for exposome-wide association studies. To highlight the advantages of silicone PSDs, we review their use in population studies and evaluate the broad range of applications and chemical classes characterized using these samplers. We assess key aspects of incorporating PSDs within observational studies, including the need to preclean samplers prior to use to remove impurities that interfere with compound detection, analytical considerations, and cost. We close with strategies on how to incorporate measures of the external exposome using PSDs, and their advantages for reducing variability in exposure measures and providing a more thorough accounting of the exposome. Continued development and application of silicone PSDs will facilitate greater understanding of how environmental exposures drive disease risk, while providing a feasible strategy for incorporating untargeted, high-resolution characterization of the external exposome in human studies.

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Section: Passive Sampling Devices For External Exposome Profilingmentioning

confidence: 99%

Operationalizing the Exposome Using Passive Silicone Samplers

et al. 2022

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“…Alkanes were used to calculate Kovat's retention indices (Kováts 1958) for all features. The work ow has been described in-depth previously (Koelmel et al 2020a).…”

Section: Suspect Screening and Data-processing Work Owmentioning

confidence: 99%

“…Manual review of 25 high con dence annotations of interest was performed to validate the method, as well as con rmation of the top hit from the scoring method using over 70 standards. Following ranking of con dence, blank feature ltering (BFF) (Patterson et al 2017), duplicate removal (by name and CAS-RN), batch-wise median normalization, and TIC recalculation was performed as described previously (Koelmel et al 2020a).…”

Section: Suspect Screening and Data-processing Work Owmentioning

confidence: 99%

“…Coupling the wristband technology with gas chromatography high-resolution mass spectrometry (GC-HRMS) enables evaluation of the occurrence, distribution, and magnitude of expected environmental contaminants of concern and screening for thousands of unexpected chemical exposures (Koelmel et al 2020a). After chemical characterization of exposure pro les, newly introduced methods can be deployed to rapidly categorize detected compounds based on toxicity using experimental and computational evidence (Martin et al 2008;BENFENATI et al 2009;Zhu et al 2009;Cassano et al 2010;Williams et al 2017;Vegosen and Martin 2020).…”

Section: Introductionmentioning

confidence: 99%

“…2.2. Wristband preparation, deployment, and gas chromatography high resolution mass spectrometry (GC-HRMS) data-acquisition Wristband preparation and data-acquisition have been previously described (Lin et al 2020;Koelmel et al 2020a). Brie y, PDMS sorbent bars were custom fabricated and cleaned in a vacuum oven (2 h, 300 °C) prior to use.…”

Section: Introductionmentioning

confidence: 99%

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Assessing the external exposome of South African children using wearable passive samplers and high-resolution mass spectrometry

Koelmel

Lin

DeLay

et al. 2021

Preprint

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Children in low- and middle-income countries are often exposed to higher levels of, and more vulnerable to, the health effects of air pollution. Little is known about the diversity, toxicity, and dynamics of airborne chemical exposures at the molecular level. We developed a workflow employing state-of-the-art wearable passive sampling technology coupled with high-resolution mass spectrometry to comprehensively measure 147 children’s personal exposures to airborne chemicals in Limpopo, South Africa, as part of the VHEMBE study. 637 environmental exposures were detected, many of which have never been measured in this population, including 50 airborne chemical exposures of concern in the children, including biocides, plasticizers, organophosphates, dyes, combustion products, and perfumes. Biocides detected in wristbands included p,p'-DDT, p,p'-DDD, p,p'-DDE, propoxur, piperonyl butoxide, and triclosan. 27% of exposures were significantly different across seasons. Our study provides the first report covering hundreds of chemical exposures among African children, demonstrating chemical exposures warranting further study.

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Charting the landscape of the environmental exposome

Wei

Huang

Jiang

et al. 2022

iMeta

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The exposome depicts the total exposures in the lifetime of an organism. Human exposome comprises exposures from environmental and humanistic sources. Biological, chemical, and physical environmental exposures pose potential health threats, especially to susceptible populations. Although still in its nascent stage, we are beginning to recognize the vast and dynamic nature of the exposome. In this review, we systematically summarize the biological and chemical environmental exposomes in three broad environmental matrices—air, soil, and water; each contains several distinct subcategories, along with a brief introduction to the physical exposome. Disease‐related environmental exposures are highlighted, and humans are also a major source of disease‐related biological exposures. We further discuss the interactions between biological, chemical, and physical exposomes. Finally, we propose a list of outstanding challenges under the exposome research framework that need to be addressed to move the field forward. Taken together, we present a detailed landscape of environmental exposome to prime researchers to join this exciting new field.

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Exploring the external exposome using wearable passive samplers - The China BAPE study

Cited by 39 publications

References 51 publications

Operationalizing the Exposome Using Passive Silicone Samplers

Operationalizing the Exposome Using Passive Silicone Samplers

Assessing the external exposome of South African children using wearable passive samplers and high-resolution mass spectrometry

Charting the landscape of the environmental exposome

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