Exploring the Formation Mechanism of Coamorphous Andrographolide-Oxymatrine Based on Molecular Dynamics and Spectroscopy

Insights into Cocrystallization and Coamorphization Engineering Techniques in the Delivery of Traditional Chinese Medicine: Formation Mechanism, Solid-State Characterization, and Improved Pharmaceutical Properties

“…Recently, Fang et al explored the formation mechanism of coamorphous andrographolide–oxymatrine through solvent evaporation and found that the formed hydrogen bonds between two components were irregular and intermittent in the solvent system. Upon the evaporation of solvent, the coamorphous solid in which components were bonded via hydrogen bonds rapidly precipitated . Moreover, the selection of solvent is crucial to the formation, yield, and stability of coamorphous combinations.…”

“…Upon the evaporation of solvent, the coamorphous solid in which components were bonded via hydrogen bonds rapidly precipitated. 97 Moreover, the selection of solvent is crucial to the formation, yield, and stability of coamorphous combinations. Solvent residues should also be evaluated given the potential risk for solvent-induced crystal transformation or solvate generation.…”

“…162 The coamorphous system of andrographolide with oxymatrine at a 1:1 molar ratio was characterized as a homogeneous amorphous phase with a single T g at 75.1 °C using DSC. 97 However, sometimes DSC is unable to detect the formation of coamorphous system containing a strong glass material because of a broad step change at T g over a wide temperature range, resulting in two T g values coexisting at one transition temperature. 159 In addition, the determination of T g is very crucial to predict the physical stability and provide a guidance for the selection of storage conditions for amorphous materials.…”

“…Han et al found that coamorphous curcumin–magnolol (1:1 molar ratio) exhibited one T g at 21.1 °C . The coamorphous system of andrographolide with oxymatrine at a 1:1 molar ratio was characterized as a homogeneous amorphous phase with a single T g at 75.1 °C using DSC . However, sometimes DSC is unable to detect the formation of coamorphous system containing a strong glass material because of a broad step change at T g over a wide temperature range, resulting in two T g values coexisting at one transition temperature .…”

Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

“…1b) is an alkaloid extracted from the plant Sophora flavescens, which is a white crystalline solid. 23 OMT has a variety of pharmacological activities, including antibacterial, antiviral, antitumor, and immunomodulatory effects. 38,39 Similarly, OMT is also widely used in cosmetics as an anti-inflammatory, 40 antioxidant, 41 and freckling ingredient.…”