Exploring the hypoglycaemic efficacy of bio-accessed antioxidative polyphenolics in thermally processed Cucumis dipsaceus fruits – An in vitro and in silico study

Paul, Benedict Mathews; Jagadeesan, Gayathri; Kannan, Gowtham; Jegan Raj, Francis; Annadurai, Yamuna; Piramanayagam, Shanmughavel; Thangaraj, Parimelazhagan

doi:10.1016/j.foodchem.2023.137577

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…The antioxidant properties of these polyphenols were found to impede the breakdown of dietary carbohydrates and mitigate the effects of T2D mellitus. Additionally, a link was established between the anti-diabetic attributes of these phenolic compounds and their bioaccessibility, suggesting that they show potential for use in diabetes prevention and postponement [ 113 ].…”

Section: Recent Studies and Emerging Trends On Polyphenolsmentioning

confidence: 99%

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

El Oirdi

2024

Pharmaceuticals

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There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both in vitro and in vivo, as well as clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, and health advantages. Dietary polyphenols have demonstrated the potential to prevent many health problems, including obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, and neurological diseases. In this paper, the protective effects of polyphenols and the mechanisms behind them are investigated in detail, citing the most recent available literature. This review aims to provide a comprehensive overview of the current knowledge on the role of polyphenols in preventing and managing chronic diseases. The cited publications are derived from in vitro, in vivo, and human-based studies and clinical trials. A more complete understanding of these naturally occurring metabolites will pave the way for the development of novel polyphenol-rich diet and drug development programs. This, in turn, provides further evidence of their health benefits.

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Section: Recent Studies and Emerging Trends On Polyphenolsmentioning

confidence: 99%

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

El Oirdi

2024

Pharmaceuticals

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GC‐MS/HPLC Profiling and Sono‐Maceration Mediated Extraction of Osbeckia Parvifolia Polyphenols: In Silico and In Vitro Analysis on Anti‐Proliferative Activity in Ovarian Cancer Cell Lines

Mathews Paul,

Kannan,

Jegan Raj

et al. 2024

Chemistry & Biodiversity

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Osbeckia parvifolia, an endemic edible plant of Western Ghats, was investigated in the present study for its polyphenolic compounds, including content, constituents, extraction through an ultrasonic‐assisted maceration technique and therapeutic potential in biomedical applications. The methanolic extract (OPM) exhibited an IC50 value of 1.25 µg/mL against 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) radicals. Furthermore, the ethyl acetate and methanolic extracts also strongly inhibited 5‐lipoxygenase, especially OPM (84.93%), which was comparable to standard curcumin. OPM also elicited cytotoxicity in SKOV3 ovarian cancer cells (93.80%), surpassing paclitaxel. Bio‐accessibility analysis demonstrated that the release of phenolic compounds and antioxidant potential were very high (above 100%), revealing the possibility of synergistic efficacy of polyphenolic complexes in drug development. Gas Chromatography ‐Mass Spectrometry (GC‐MS) analysis revealed 22 bioactive polyphenolic compounds in OPM, such as epicatechin, quercetin, and psoralidin. This was confirmed by High Performance Liquid Chromatography (HPLC) and High‐Pressure Thin Layer Chromatography (HPTLC) analyses, which revealed a high quantity of catechin (37.45 mg/g). Molecular docking revealed the significant binding affinity of these proteins for the ovarian oncoproteins PI3K (‐8.52 kcal/mol) and Casp‐8 (‐8.41 kcal/mol). Adsorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) profiling indicated the favorable pharmacokinetic properties of these compounds, supporting their candidacy in drug formulations against ovarian cancer.

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Phytochemical composition, simulated digestive bioaccessibility and cytotoxicity of Ficus auriculata Lour. fruits: In vitro and in silico insights

Jenipher,

Amalraj,

Kalaskar

et al. 2025

Food Chemistry

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Exploring the hypoglycaemic efficacy of bio-accessed antioxidative polyphenolics in thermally processed Cucumis dipsaceus fruits – An in vitro and in silico study

Cited by 6 publications

References 22 publications

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

GC‐MS/HPLC Profiling and Sono‐Maceration Mediated Extraction of Osbeckia Parvifolia Polyphenols: In Silico and In Vitro Analysis on Anti‐Proliferative Activity in Ovarian Cancer Cell Lines

Phytochemical composition, simulated digestive bioaccessibility and cytotoxicity of Ficus auriculata Lour. fruits: In vitro and in silico insights

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