Exploring the <i>in vitro</i> potential of royal jelly against glioblastoma and neuroblastoma: impact on cell proliferation, apoptosis, cell cycle, and the biomolecular content

Simsek Ozek, Nihal

doi:10.1039/d3an01840g

Cited by 1 publication

(1 citation statement)

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“…As mentioned in previous sections, 10-HDA acts as a potent HDAC inhibitor and suppresses proliferation by inhibiting PI3K/Akt signaling [ 47 , 88 ]. The lipophilic extract of RJ demonstrated the antiproliferative effects in human neuroblastoma cells (SH-SY5Y) and human glioblastoma (U373) [ 237 , 238 ]. Treatment with a high dose of RJ significantly increased the apoptotic cell population of both SH-SY5Y-human neuroblastoma and U373-human glioblastoma and arrested the cell cycle at the G0–G1 phase in SH-SY5Y cells and at G2–M in U373 cells.…”

Section: Biological Function Of Royal Jellymentioning

confidence: 99%

Royal Jelly: Biological Action and Health Benefits

Oršolić,

Jazvinšćak Jembrek

2024

IJMS

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Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as a health-promoting food. This bee product is a mixture of important compounds, such as proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, and polyphenols, that underlie the remarkable biological and therapeutic activities of RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, the major royal jelly proteins, and specific peptides such as apisimin, royalisin, royalactin, apidaecin, defensin-1, and jelleins are characteristic ingredients of RJ. RJ shows numerous physiological and pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, and anti-tumor effects. Moreover, RJ may reduce menopause symptoms and improve the health of the reproductive system, liver, and kidneys, and promote wound healing. This article provides an overview of the molecular mechanisms underlying the beneficial effects of RJ in various diseases, aging, and aging-related complications, with special emphasis on the bioactive components of RJ and their health-promoting properties. The data presented should be an incentive for future clinical studies that hopefully will advance our knowledge about the therapeutic potential of RJ and facilitate the development of novel RJ-based therapeutic opportunities for improving human health and well-being.

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