Exploring the immune response, tolerance and resistance in proliferative kidney disease of salmonids

Bailey, Christyn; Strepparava, Nicole; Wahli, Thomas; Segner, Helmut

doi:10.1016/j.dci.2018.09.015

Cited by 37 publications

(69 citation statements)

References 67 publications

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“…Copepoda) in Leuciscus burdigalensis has been shown by Blanchet, Rey, and Loot (2010). Bailey, Strepparava, Wahli, and Segner (2019) The basic theories of genetic polymorphism in the host defence against pathogens include Red queen dynamics (Van Valen, 1973).…”

Section: Discussionmentioning

confidence: 99%

Genetically determined resistance and tolerance to Diplostomum sp. parasite in farmed rainbow trout

et al. 2020

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Parasite infectivity, virulence and host resistance have been in the centre of the scientific interest when it comes to host-parasite relationships. In addition to resistance, hosts may also vary in their tolerance against parasites. This is important to notice because resistance and tolerance have different consequences in host-parasite co-evolution. Here, we show that families of farmed rainbow trout (Oncorhynchus mykiss) show both host defence strategies, resistance, and tolerance, against infectivity and virulence of Diplostomum sp. (Trematoda) parasites. Both strategies have moderate genetic variation and are genetically independent of each other. It is also shown that the families having the highest performance measured as higher weight, better condition factor and lower mortality in absence of the parasites suffer the most when parasitism increases. For practical breeding programmes, this means that both resistance and tolerance can be improved by selection without compromising one of the strategies. These results give new insight into defence strategies against parasites in fish and into processes of fish-parasite co-evolution.

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Section: Discussionmentioning

confidence: 99%

Genetically determined resistance and tolerance to Diplostomum sp. parasite in farmed rainbow trout

et al. 2020

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“…При этом было установлено достоверное увеличение данных показателей при экспериментальной интоксикации кадмием. О роли иммунных процессов в развитии и течении почечной патологии у рыб отмечается и в ряде новых публикаций [14,11].…”

Section: результаты и обсуждениеunclassified

“…Известно, что иммунным процессам принадлежит ведущая роль в развитии многих форм почечной патологии [3]. Показано, в частности, развитие иммунного ответа при пролиферативной болезни почек лососёвых рыб [11]. Вместе с тем вопросы развития почечной патологии при интоксикации кадмием и протекание тех или иных процессов в иммунной системе у рыб практические не отражены в доступной нам литературе.…”

Section: Introductionunclassified

The effect of experimental intoxication with cadmium on the morphological and functional indicators of kidneys of fish

Kryuchkov¹,

Бутаева²,

Omarova³

et al. 2018

HDSU

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“…T. bryosalmonae spores are released from the definitive bryozoan host, Fredericella sultana 4,5 and, following attachment, invade fish hosts via skin epidermal mucous cells (in gills and elsewhere) and migrate through the vascular system to the kidney and other organs, including spleen and liver 6 . Extrasporogonic proliferation of T. bryosalmonae in kidney tissues elicits a chronic tissue pathology, characterised by lymphoid hyperplasia, granulomatous lesions, renal atrophy, anaemia 7,8 and hyper secretion of immunoglobulins 9,10 . The severity and development of these hallmark symptoms of PKD are modified by a variety of biological, environmental and chemical stressors, impacting on parasite load, host immunity, and disease recovery 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Extrasporogonic proliferation of T. bryosalmonae in kidney tissues elicits a chronic tissue pathology, characterised by lymphoid hyperplasia, granulomatous lesions, renal atrophy, anaemia 7,8 and hyper secretion of immunoglobulins 9,10 . The severity and development of these hallmark symptoms of PKD are modified by a variety of biological, environmental and chemical stressors, impacting on parasite load, host immunity, and disease recovery 10,11 . A genetic basis for such pathological and developmental variation is evidenced by introduced, non-co-evolved salmonid hosts in Europe, such as rainbow trout, acting as dead-end hosts.…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomics and host-specific parasite gene expression profiles inform on drivers of proliferative kidney disease

Faber

Yoon

Shaw

et al. 2020

Preprint

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The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease (PKD), characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understanding of T. bryosalmonae-host interactions, we have adopted a two-host parasite transcriptome sequencing approach to minimize host contamination in the absence of a complete T. bryosalmonae genome. Parasite contigs common to both infected hosts (the intersect transcriptome; 7,362 contigs) were typically AT-rich (60-75% AT). 5,432 contigs within the intersect were annotated with 1,930 unannotatde contigs encoding for unknown transcripts. We have focused on transcripts encoding proteins involved in; nutrient acquisition, host-parasite interactions, development, and cell-to-cell communication or proteins of unknown function, establishing their potential importance in each host by RT-qPCR. Host-specific expression profiles were evident, particularly in transcripts encoding proteases and proteins involved in lipid metabolism, cell adhesion, and development. We confirm for the first time the presence of homeobox proteins and a frizzled homologue in myxozoan parasites.The novel insights into myxozoan biology that this study reveals will help to focus research in developing future disease control strategies.

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Exploring the immune response, tolerance and resistance in proliferative kidney disease of salmonids

Cited by 37 publications

References 67 publications

Genetically determined resistance and tolerance to Diplostomum sp. parasite in farmed rainbow trout

Genetically determined resistance and tolerance to Diplostomum sp. parasite in farmed rainbow trout

The effect of experimental intoxication with cadmium on the morphological and functional indicators of kidneys of fish

Comparative transcriptomics and host-specific parasite gene expression profiles inform on drivers of proliferative kidney disease

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