Exploring the impact of Helicobacter pylori and potential gut microbiome modulation

Abstract

Helicobacter pylori is a highly prevalent bacteria that can harm humans due to its major involvement in developing gastrointestinal diseases, particularly gastric cancer. Therefore, eradicating H. pylori is one of the most important strategies for preventing gastric cancer. Antibiotic treatment has always been the gold standard treatment for H. pylori infection. However, the decreasing efficacy of antibiotic therapy due to the rising antibiotic resistance and high incidence of dysbiosis-related adverse effects resulted in eradication failure. To enhance the effectiveness of antibiotic therapy, strategies that modulate the gut microbiome were proposed to play a positive role. Generally, the integration of probiotics or symbiotic into antibiotic therapy was shown to enhance the eradication rate and reduce the incidence of adverse effects. This review aims to discuss the role and effect of H. pylori in gastric carcinogenesis and gut microbiome modulation in eradicating H. pylori infection.

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

“…Gastrointestinal infections, such as Helicobacter pylori infection and foodborne illnesses, have also been linked to dysbiosis [27][28][29]. H. pylori is a bacterium that colonizes the stomach and is associated with various gastrointestinal disorders, including gastric ulcers and stomach cancer.…”

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

“…However, the sustainability of the baseline microbial pattern becomes a matter of concern owing to the possibly harmful interference of various internal and external stimuli at any given stage of life [ 64 , 68 , 69 ]. An untoward perturbation of the baseline gut microbial composition favors the pathogenic activity of the indigenous symbionts of the gut, hence giving rise to pathobionts that may, in turn, adversely affect the host’s physiology [ 70 , 71 , 72 , 73 , 74 , 75 ].…”

Bioactive peptides as alternative treatment for Helicobacter pylori infection

“…Furthermore, the pathogen dynamics with the microbiota of the gastrointestinal tract is highly complex, and eradication not only affects the gastrointestinal tract itself, but also its absence has been associated with dysbiosis and the emergence of a variety of systemic disorders, weight gain or loss, and susceptibility to allergic diseases such as asthma [43,[74][75][76][77][78][79]. In contrast, research over the years has demonstrated that eradicating H. pylori prior to the onset of precancerous histological changes can prevent the development of gastric cancer and dysbiosis can be managed with the integration to the antibiotic treatment of probiotics and other alternatives for microbiota modulation [80][81][82]. This forms the basis for the screen-and-treat approach to H. pylori infection and optimization strategies such as family-based.…”