This study investigates the impacts of Land Use/Land Cover (LULC) changes and climate change on surface runoff in Gdańsk, Poland, which is crucial for local LULC planning and urban flood risk management. The analysis employs two primary methodologies: remote sensing and hydrological modeling. Remote sensing was conducted using Google Earth Engine and Land Change Modeler in IDRISI Terrset software to analyze historical (1985–2022) and future (2050–2100) LULC. Hydrological modeling was performed using the Natural Resources Conservation Service curve number method to assess the overall impact of LULC changes on Gdańsk’s hydrology at the local scale. The Orunia basin, a critical area due to intensive LULC development, was selected for detailed hydrological analysis using the Hydrologic Modeling System (HEC-HMS). The analysis encompassed three scenarios: LULC changes, climate change, and combined LULC and climate change effects. The LULC analysis revealed a marked increase in urban area, a shift in forest and vegetation cover, and a reduction in agricultural land. HEC-HMS simulations showed an increase in the runoff coefficient across selected decades, which was attributed to the combined effect of LULC and climate change. The projected increases under the Representative Concentration Pathway (RCP) 4.5 and RCP 8.5 scenarios for 2050 and 2100 are projected to surpass those observed during the baseline period. The findings highlight that the synergistic effects of LULC and climate change have a more significant impact on Gdańsk’s hydrology at both local and basin scales than their separate effects. These insights into LULC shifts and urban hydrological responses hold implications for sustainable urban planning and effective flood risk management in Gdańsk and similar urban settings.