Exploring the impact of mental health conditions on vaccine uptake in high-income countries: a systematic review

Suffel, Anne M; Ojo-Aromokudu, Oyinkansola; Carreira, Helena; Mounier-Jack, Sandra; Osborn, David; Warren‐Gash, Charlotte; Mcdonald, Helen

doi:10.1186/s12888-022-04512-y

Cited by 12 publications

(4 citation statements)

References 55 publications

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“…Vaccination is a pivotal public health intervention, substantially reducing morbidity and mortality associated with infectious diseases [ 1 , 2 , 3 ]. Immunization programs have contributed to a significant decline in the global burden of vaccine-preventable diseases, thus enhancing millions of individuals’ overall quality of life [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Impact on DTP Vaccination Trends in Africa: A Joinpoint Regression Analysis

Aguinaga-Ontoso

Guillen-Aguinaga

et al. 2023

Vaccines

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Background: Deaths due to vaccine-preventable diseases are one of the leading causes of death among African children. Vaccine coverage is an essential measure to decrease infant mortality. The COVID-19 pandemic has affected the healthcare system and may have disrupted vaccine coverage. Methods: DTP third doses (DTP3) Vaccine Coverage was extracted from UNICEF databases from 2012 to 2021 (the last available date). Joinpoint regression was performed to detect the point where the trend changed. The annual percentage change (APC) with 95% confidence intervals (95% CI) was calculated for Africa and the regions. We compared DTP3 vaccination coverage in 2019–2021 in each country using the Chi-square test. Result: During the whole period, the vaccine coverage in Africa increased with an Annual Percent change of 1.2% (IC 95% 0.9–1.5): We detected one joinpoint in 2019. In 2019–2021, there was a decrease in DTP3 coverage with an APC of −3.5 (95% −6.0; −0,9). (p < 0.001). Vaccination rates decreased in many regions of Sub-Saharan Africa, especially in Eastern and Southern Africa. There were 26 countries (Angola, Cabo Verde, Comoros, Congo, Côte d’Ivoire, Democratic Republic of the Congo, Djibouti, Ethiopia, Eswatini, The Gambia, Guinea-Bissau, Liberia, Madagascar, Malawi, Mauritania, Mauritius, Mozambique, Rwanda, Senegal, Seychelles, Sierra Leone, Sudan, Tanzania, Togo, Tunisia, Uganda, and Zimbabwe) where the vaccine coverage during the two years decreased. There were 10 countries (Angola, Cabo Verde, Comoros, Democratic Republic of the Congo, Eswatini, The Gambia, Mozambique, Rwanda, Senegal, and Sudan) where the joinpoint regression detected a change in the trend. Conclusions. COVID-19 has disrupted vaccine coverage, decreasing it all over Africa.

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Section: Introductionmentioning

confidence: 99%

COVID-19 Impact on DTP Vaccination Trends in Africa: A Joinpoint Regression Analysis

Aguinaga-Ontoso

Guillen-Aguinaga

et al. 2023

Vaccines

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“…Previous systematic reviews exploring the association between mental illness and uptake of various vaccinations have reported heterogenous results. (8, 9) Similarly, results from previous country-specific studies of COVID-19 vaccination uptake in people with mental illness have been inconsistent. While some studies have observed significantly lower uptake of COVID-19 vaccination among individuals with mental illness,(10, 11) others have either reported higher uptake (12), no significant difference,(13) or differences in uptake according to the type of mental illness.…”

Section: Introductionmentioning

confidence: 99%

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Barker,

Kõiv,

Magnúsdóttir

et al. 2024

Preprint

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Background: Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Therefore, we aimed to investigate the association between mental illness and COVID-19 vaccination uptake, using data from five countries. Methods: Data from seven cohort studies (N=325,298), and the Swedish registers (8,080,234), were used to identify mental illness and COVID-19 vaccination uptake. Multivariable modified Poisson regression models were conducted to calculate the prevalence ratio (PR) and 95% CIs of vaccination uptake among individuals with v.s. without mental illness. Results from the cohort studies were pooled using random effects meta-analyses. Findings: Most of the meta-analyses performed using the COVIDMENT study population showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first (prevalence ratio [PR]: 0.98, 95% CI: 0.98-0.99, p<0.001) and second dose among individuals with mental illness; the reduction was however greater among those not using pyschiatric medication (PR: 0.91, 95% CI: 0.91-0.91, p<0.001). Conclusions: The high uptake of COVID-19 vaccination observed among individuals with most types of mental illness highlights the comprehensiveness of the vaccination campaign , however lower levels of vaccination uptake among subgroups of individuals with unmedicated mental illness warrants attention in future vaccination campaigns.

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“…Immunization is a cornerstone in public health, pivotal in diminishing the prevalence and severity of infectious diseases and their effects on health outcomes [ 1 , 2 , 3 ]. Vaccine-preventable diseases remain a significant public health concern globally.…”

Section: Introductionmentioning

confidence: 99%

Has COVID-19 Affected DTP3 Vaccination in the Americas?

Aguinaga-Ontoso,

Guillén-Aguinaga,

Guillén-Aguinaga

et al. 2024

Vaccines

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Background: In the Americas, deaths by diseases avoidable with vaccines are a significant contributor to child mortality. An essential means of reducing this is through broad vaccine coverage. The COVID-19 pandemic has posed a potential disruption to vaccine coverage due to its effects on the healthcare system. Objectives: this study aims to evaluate the impact of the COVID-19 pandemic on DTP3 vaccination coverage in the Americas, investigating trends from 2012 to 2022 to identify significant changes, regional disparities, and the overall effect of the pandemic on progress towards global immunization targets. Methods: This study used the coverage data for the third dose of the diphtheria, tetanus, and pertussis vaccine (DTP3) pulled from UNICEF databases spanning 2012 to 2022. We conducted a Joinpoint regression to identify points of significant trend changes. The annual percentage change (APC) and 95% confidence intervals (95% CIs) were calculated for America and its regions. We also used segmented regression analysis. Using the Chi-square test, we compared DTP3 vaccination coverage for each country between 2019 and 2022. Results: Overall, America saw a decrease in vaccine coverage during this period, with an APC of −1.4 (95% CI −1.8; −1.0). This trend varied across regions. In North America, the decrease was negligible (−0.1% APC). South America showed the steepest decrease, with an APC of −2.5%. Central America also declined, with an APC of −1.3%. Our findings suggest a concerning trend of declining DTP-vaccination rates in the Americas, exacerbated in certain regions, in the wake of the COVID-19 pandemic. The absolute decrease in vaccine coverage in the Americas was −4% between 2019 and 2022, with the most important drop being in Central America (−7%). However, six countries reported increased vaccination rates post-COVID-19, led by Brazil, with a 7% increase. Conversely, twenty-two countries registered a decline in DTP3 vaccine coverage, with the average decrease being −7.37%. This decline poses an important challenge to achieving the WHO’s target of 90% coverage for the third dose of DTP by 2030, as evidenced by the reduction in the number of countries meeting this target from 2019 to 2022. Conclusions: The COVID-19 pandemic has impacted vaccine coverage in America, leading to a decrease, especially across Central America.

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Exploring the impact of mental health conditions on vaccine uptake in high-income countries: a systematic review

Cited by 12 publications

References 55 publications

COVID-19 Impact on DTP Vaccination Trends in Africa: A Joinpoint Regression Analysis

COVID-19 Impact on DTP Vaccination Trends in Africa: A Joinpoint Regression Analysis

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Has COVID-19 Affected DTP3 Vaccination in the Americas?

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