Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models

Caon, Elisabetta; Martins, Maria; Hodgetts, Harry; Blanken, Lieke; Vilia, Maria Giovanna; Levi, Ana; Thanapirom, Kessarin; Al-Akkad, Walid; Abu-Hanna, Jeries; Baselli, Guido; Hall, Andrew R.; Luong, Tu Vinh; Taanman, Jan-Willem; Vacca, Michele; Valenti, Luca; Romeo, Stefano; Mazza, Giuseppe; Pinzani, Massimo; Rombouts, Krista

doi:10.1016/j.jhep.2024.01.032

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article4

Preprint1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 8 publications

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Metabolic reprogramming in liver fibrosis

Horn,

Tacke

2024

Cell Metabolism

View full text Add to dashboard Cite

Metabolic reprogramming in liver fibrosis

Horn,

Tacke

2024

Cell Metabolism

View full text Add to dashboard Cite

lncRNA-NEF regulates hepatic stellate cells proliferation, cell cycle, apoptosis and ECM synthesis through the ERK1/2/c-Fos axis

Jia,

Lu,

et al. 2025

Experimental Cell Research

View full text Add to dashboard Cite

Mechanisms coupling lipid droplets to MASLD pathophysiology

Reid,

Fredickson,

Mashek

2024

Hepatology

View full text Add to dashboard Cite

Hepatic steatosis, the buildup of neutral lipids in lipid droplets (LDs), is commonly referred to as metabolic dysfunction-associated steatotic liver disease (MASLD) when alcohol or viral infections are not involved. MASLD encompasses simple steatosis and the more severe metabolic dysfunction-associated steatohepatitis (MASH), characterized by inflammation, hepatocyte injury, and fibrosis. Previously viewed as inert markers of disease, LDs are now understood to play active roles in disease etiology and have significant non-pathological and pathological functions in cell signaling and function. These dynamic properties of LDs are tightly regulated by hundreds of proteins that coat the LD surface, controlling lipid metabolism, trafficking, and signaling. The following review highlights various facets of LD biology with the primary goal of discussing key mechanisms through which LDs can promote the development of advanced liver diseases including MASH.

show abstract

Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models

Cited by 8 publications

References 85 publications

Metabolic reprogramming in liver fibrosis

Metabolic reprogramming in liver fibrosis

lncRNA-NEF regulates hepatic stellate cells proliferation, cell cycle, apoptosis and ECM synthesis through the ERK1/2/c-Fos axis

Mechanisms coupling lipid droplets to MASLD pathophysiology

Contact Info

Product

Resources

About