Exploring the interaction mechanism of a dicarboxamide fungicide, iprodione with bovine serum albumin

Tayyab, Saad; Min, Loh Hui; Kabir, Md. Zahirul; Kandandapani, Salanee; Ridzwan, Nor Farrah Wahidah; Mohamad, Saharuddin Bin

doi:10.1007/s11696-019-01015-1

Cited by 19 publications

(6 citation statements)

References 49 publications

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“…A fixed amount of the L1 – L5 and complexes Q1 – Q15 (50 µM) were prepared by dissolving an appropriate amount in DMSO. At a low DMSO concentration, the stability of biomolecules is known to be retained [ 106 , 107 ]. Therefore, in all the experimental of the interaction of L1 – L5 and complexes Q1 – Q15 with biomolecules, the final concentration of DMSO in the incubation mixture was ~2% ( v / v ).…”

Section: Methodsmentioning

confidence: 99%

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities

et al. 2021

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A series of fifteen silver (I) quinoline complexes Q1–Q15 have been synthesized and studied for their biological activities. Q1–Q15 were synthesized from the reactions of quinolinyl Schiff base derivatives L1–L5 (obtained by condensing 2-quinolinecarboxaldehyde with various aniline derivatives) with AgNO3, AgClO4 and AgCF3SO3. Q1–Q15 were characterized by various spectroscopic techniques and the structures of [Ag(L1)2]NO3Q1, [Ag(L1)2]ClO4Q6, [Ag(L2)2]ClO4Q7, [Ag(L2)2]CF3SO3Q12 and [Ag(L4)2]CF3SO3Q14 were unequivocally determined by single crystal X-ray diffraction analysis. In vitro antimicrobial tests against Gram-positive and Gram-negative bacteria revealed the influence of structure and anion on the complexes′ moderate to excellent antibacterial activity. In vitro antioxidant activities of the complexes showed their good radical scavenging activity in ferric reducing antioxidant power (FRAP). Complexes with the fluorine substituent or the thiophene or benzothiazole moieties are more potent with IC50 between 0.95 and 2.22 mg/mL than the standard used, ascorbic acid (2.68 mg/mL). The compounds showed a strong binding affinity with calf thymus-DNA via an intercalation mode and protein through a static quenching mechanism. Cytotoxicity activity was examined against three carcinoma cell lines (HELA, MDA-MB231, and SHSY5Y). [Ag(L2)2]ClO4Q7 with a benzothiazole moiety and [Ag(L4)2]ClO4Q9 with a methyl substituent had excellent cytotoxicity against HELA cells.

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Section: Methodsmentioning

confidence: 99%

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities

et al. 2021

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“…FT-IR spectroscopy is another valuable spectroscopic technique used in determining changes in the native conformation or secondary structure of macromolecules including proteins [25,43].…”

Section: Fourier Transform-infrared (Ft-ir) Spectroscopymentioning

confidence: 99%

“…4A(A1)]. Peak positions between 3200 and 3550 cm À1 were attributed to O-H stretching of hydroxyl groups in the enzyme molecule which consists of polar amino acid residues such as tyrosine, serine and threonine amongst other residues [42,43]. In proteins generally, two categories of amide bond peak positions exist.…”

Section: Fourier Transform-infrared (Ft-ir) Spectroscopymentioning

confidence: 99%

“…In proteins generally, two categories of amide bond peak positions exist. These are known as the amide I band or region characterized by absorption peaks between 1700 and 1600 cm À1 (C = O stretching) and amide II band denoted by peaks between 1600 and 1500 cm À1 (C-N stretching coupled with N-H bending mode) [25,43]. While both amide I and amide II bands are unique to all proteins, the amide I spectra region is more important and frequently reported in studies due to its high sensitivity to changes in protein secondary structure [42].…”

Section: Fourier Transform-infrared (Ft-ir) Spectroscopymentioning

confidence: 99%

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α-Amylase inhibition, anti-glycation property and characterization of the binding interaction of citric acid with α-amylase using multiple spectroscopic, kinetics and molecular docking approaches

Avwioroko

Anigboro

Otuechere

et al. 2022

Journal of Molecular Liquids

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“…The protein is characterized by natural fluorescent prop a consequence of two tryptophan residues (Trp 134 and 213) and multiple tyrosi and phenylalanine (Phe) moieties (Figure 7) [161]. This peculiar feature can be ex to investigate BSA-drug interactions, as was true for the anti-tumoral com neratinib [162] and linifanib [163] as well as for the antimycotic iprodione [164]. The gelation mechanism of BSA involves a rearrangement of the tertiary structure of the protein due to the unfolding of certain polypeptides.…”

Section: Bovine Serum Albumin-(bsa) Based Hydrogelsmentioning

confidence: 99%

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Voci

Gagliardi

Molinaro

et al. 2021

Gels

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The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

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Exploring the interaction mechanism of a dicarboxamide fungicide, iprodione with bovine serum albumin

Cited by 19 publications

References 49 publications

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities

α-Amylase inhibition, anti-glycation property and characterization of the binding interaction of citric acid with α-amylase using multiple spectroscopic, kinetics and molecular docking approaches

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

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