Exploring the interaction of Valsartan and Valsartan-Zn(ll) complex with DNA by spectroscopic and in silico methods

Kale, Kishor B.; Shinde, Mandakini; Patil, Rajendra; Ottoor, Divya

doi:10.1016/j.saa.2021.120329

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…The point of intersection was found at 0.65, which suggested a 1:2 metal-to-ligand [ M/HL ] stoichiometric ratio, in agreement with related studies. 63 − 65 Similarly, the formation constant ( K ) was evaluated spectroscopically at different temperatures ( Table S2 ). From the extrapolated Job’s plot ( Figure S4A,B ), both the Zn(II) and Cu(II) complexes have K values of 2.47 × 10 8 and 4.29 × 10 8 , respectively, which is in line with previously reported studies ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Damena

Alem

Zeleke³

et al. 2022

ACS Omega

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In the present work, two novel complexes of zinc(II) and copper(II) were synthesized from the ligand 2-((2-hydroxyethyl)amino)quinoline-3-carbaldehyde ( H 2 L ) in a 1:2 metal-to-ligand ratio in methanol. The complexes were characterized by UV–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDX), mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and thermogravimetric analysis (TGA) experimental techniques and density functional theory (DFT) calculations. The spectral data revealed that the mono-deprotonated ( HL ) ligand acted as a bidentate ligand, which bound to both Zn(II) and Cu(II) ions via the nitrogen atom of the amine (N–H) and the hydroxyl (O–H) groups through the deprotonated oxygen atom. Formation constants and thermal analysis indicated that both metal complexes are stable up to 100 °C with thermodynamically favored chemical reactions. The Cu(II) complex showed antibacterial activities with the zones of inhibition of 20.90 ± 2.00 mm against Pseudomonas aeruginosa , 19.69 ± 0.71 mm against Staphylococcus aureus , and 18.58 ± 1.04 mm against Streptococcus pyogenes . These results are relatively higher compared with the Zn(II) complex at the same concentration. The minimum inhibitory concentration (MIC) results for the complexes also showed similar trends against the three bacteria. On the other hand, radical scavenging activities of both Cu(II) and Zn(II) complexes showed half-maximal inhibitory concentrations (IC 50 ) of 4.72 and 8.2 μg/mL, respectively, while ascorbic acid (a positive control) has a value of 4.28 μg/mL. The Cu(II) complex exhibited better communication with the positive control, indicating its potential use for biological activities. The calculated and in silico molecular docking results also strongly support the experimental results.

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Section: Resultsmentioning

confidence: 99%

“…From the extrapolated Job’s plot (Figure S4A,B), both the Zn(II) and Cu(II) complexes have K values of 2.47 × 10 8 and 4.29 × 10 8 , respectively, which is in line with previously reported studies (Table ). ,− …”

Section: Resultsmentioning

confidence: 99%

Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Damena

Alem

Zeleke³

et al. 2022

ACS Omega

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“…In this case, complex 2b favourably interacts with DNA compared to complex 1a and 2a. The magnitude of Stern Volmer quenching constant for complexes 1a , 2a and 2b were similar to the non-intercalator compounds, which interact electrostatically with DNA. 30,32,36,37…”

Section: Resultsmentioning

confidence: 99%

“…The magnitude of Stern Volmer quenching constant for complexes 1a, 2a and 2b were similar to the non-intercalator compounds, which interact electrostatically with DNA. 30,32,36,37 3.2.3. Viscosity measurements.…”

Section: Dna Binding Studiesmentioning

confidence: 99%

Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor

et al. 2023

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Investigation of H-Bonding and pH on the Fluorescence Spectral Behavior of Valsartan

Yousef,

Ghanem,

Almashaqbeh

et al. 2024

J Fluoresc

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Exploring the interaction of Valsartan and Valsartan-Zn(ll) complex with DNA by spectroscopic and in silico methods

Cited by 6 publications

References 51 publications

Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Novel Zinc(II) and Copper(II) Complexes of 2-((2-Hydroxyethyl)amino)quinoline-3-carbaldehyde for Antibacterial and Antioxidant Activities: A Combined Experimental, DFT, and Docking Studies

Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor

Investigation of H-Bonding and pH on the Fluorescence Spectral Behavior of Valsartan

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