It is common for higher education institutions (HEIs) in the United States (USA) to pursue internationalization through multiple approaches, including developing a global curriculum, hosting international students and scholars, promoting study abroad programs, and establishing cross-border partnerships. The push toward internationalized HEIs can contribute to the reification of Western imperialism, academic colonization, and inequality. In this chapter, we use equity as a foundation to analyze research on the concept of internationalization, the historical progressions of internationalization practice in the USA, and the multiple forms of internationalization practices at US HEIs. We articulate the potential for research on US higher education internationalization to be equity driven and offer considerations for how researchers and practitioners can center power and equity as they engage in investigating or implementing internationalization processes. We recommend interrogating how, by whom, and for whom internationalization is defined; using a structural lens that bridges internationalization to its primary driver – globalization – and viewing internationalization as the amalgamation of multiple complex practices.