2023
DOI: 10.1002/cnr2.1953
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Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer

Tatjana Vlajnic,
David C. Müller,
Christian Ruiz
et al.

Abstract: BackgroundProstate cancer is morphologically and molecularly heterogeneous. Genomic heterogeneity might be mirrored by variability in DNA ploidy. Aneuploidy is a hallmark of genomic instability and associated with tumor aggressiveness. Little attention has been paid to the biological significance of the diploid tumor cell population that often coexists with aneuploid populations. Here, we investigated the role of DNA ploidy in tumor heterogeneity and clonal evolution.MethodsThree radical prostatectomy specimen… Show more

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