Exploring the intricacies of calcium dysregulation in ischemic stroke: Insights into neuronal cell death and therapeutic strategies

Rahi, Vikrant; Kaundal, Ravinder K.

doi:10.1016/j.lfs.2024.122651

Life Sciences

2024

DOI: 10.1016/j.lfs.2024.122651

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Exploring the intricacies of calcium dysregulation in ischemic stroke: Insights into neuronal cell death and therapeutic strategies

Vikrant Rahi,

Ravinder K. Kaundal

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2024

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Cited by 8 publications

References 133 publications

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The role of metal ions in stroke: Current evidence and future perspectives

Wang,

Qin,

Fan

et al. 2024

Ageing Research Reviews

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The role of metal ions in stroke: Current evidence and future perspectives

Wang,

Qin,

Fan

et al. 2024

Ageing Research Reviews

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Current Concepts of the Role of the STEP Striatal-Enriched Protein Tyrosine Phosphatase in the Pathological and Neurodegenerative Processes in the Brain

Moskalyuk,

Kulikov,

Naumenko

et al. 2024

Nejrohimiâ

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Striatal-enriched protein tyrosine phosphatase (STEP) is an intracellular protein involved in key signaling cascades of the nerve cell. By regulating the membrane localization of glutamate receptors and the activity of several signaling kinases, STEP can influence processes of neuroplasticity and synaptic function, and participate in the regulation of behavior, cognitition, and memory. STEP can act as an intermediary between the brain’s neurotrophic, dopaminergic, and glutamatergic systems. Dysregulation of STEP expression and function is observed in several neurodegenerative and psychiatric disorders, as well as in aging and traumatic brain injuries. In Alzheimer’s and Parkinson’s diseases, as well as in fragile X syndrome, there is an increase in STEP activity and expression in the brains of patients and in animal models of these diseases. There is evidence of this phosphatase’s involvement in the mechanisms of depression, autism spectrum disorders, schizophrenia, and anxiety; however, different model systems and experimental conditions yield contradictory results. STEP plays a modulatory role in the nervous system’s response to traumatic brain injuries, ischemic stroke, epileptic seizures, and stress exposure. Due to STEP’s involvement in the pathogenesis of numerous nervous system disorders, this phosphatase has been actively studied over the past decade. In this review, we comprehensively examine the existing data on the role of STEP phosphatase in the functioning of CNS and in the mechanisms of disease development and the response of nerve cells to damaging influences.

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Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review

Mahapatra,

Thakkar,

Kumar

2024

Antioxidants

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Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses, significantly affects cellular function and viability. It plays a pivotal role in modulating membrane potentials, particularly action potentials (APs), essential for properly functioning excitable cells such as neurons, smooth muscles, pancreatic beta cells, and myocytes. The interaction between oxidative stress and AP dynamics is crucial for understanding the pathophysiology of various conditions, including neurodegenerative diseases, cardiac arrhythmias, and ischemia-reperfusion injuries. This review explores how oxidative stress influences APs, focusing on alterations in ion channel biophysics, gap junction, calcium dynamics, mitochondria, and Interstitial Cells of Cajal functions. By integrating current research, we aim to elucidate how oxidative stress contributes to disease progression and discuss potential therapeutic interventions targeting this interaction.

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Exploring the intricacies of calcium dysregulation in ischemic stroke: Insights into neuronal cell death and therapeutic strategies

Cited by 8 publications

References 133 publications

The role of metal ions in stroke: Current evidence and future perspectives

The role of metal ions in stroke: Current evidence and future perspectives

Current Concepts of the Role of the STEP Striatal-Enriched Protein Tyrosine Phosphatase in the Pathological and Neurodegenerative Processes in the Brain

Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review

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