Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action

Mitra, Saikat; Anjum, Juhaer; Muni, Maniza; Das, Rajib; Rauf, Abdur; Islam, Fahadul; Emran, Talha Bin; Semwal, Prabhakar; Hemeg, Hassan A.; Alhumaydhi, Fahad A.; Wilairatana, Polrat

doi:10.1016/j.biopha.2022.112877

Cited by 65 publications

(40 citation statements)

References 187 publications

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“…It is widely accepted that herbal products are superior to synthetic pharmaceuticals owing to the broad availability of herbal products as well as the great amount of empirical and readily available evidence about their traditional usage [ 31 – 35 ]. Modern scientific techniques, on the other hand, should be used to verify the claims made regarding the medicinal properties of plants, which would result in validation of the traditional system of medicine [ 36 – 38 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

Quazi¹,

Patwekar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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In the present investigation, Ichnocarpus frutescens, Ficus dalhousiae, Crateva magna, Alpinia galanga, and Swertia chirata plants were selected to formulate polyherbal tea bag. The infusion obtained from these polyherbal tea bags was used to formulate 5% and 10% ointment formulation to perform its wound healing activity. The excision wound model was used to assess the wound healing activity in diabetic as well nondiabetic rats. The mean percentage closure of wound area was calculated on the 3rd, 6th, 9th, 12th, 15th, 18th, and finally 21st day. The wound healing activity of formulation was found to be significantly compared with that of the reference standard and untreated groups. The percentages of closure of excision wound area on the 21st day in diabetic animals treated with ointment formulations (F1 and F2) were found to be 93.91 ± 1.65% and 99.12 ± 5.21% respectively, whereas the chloramphenicol sodium drug solution was found to be 99.81 ± 3.16%. The percentages of closure of excision wound area in nondiabetic animals treated with ointment formulations (F1 and F2) were found to be 96.81 ± 2.04% and 98.13 ± 1.14%, respectively, whereas the chloramphenicol sodium drug solution was found to be 99.15 ± 1.41% at 21st day. Therefore, from the above results, we have concluded that this polyherbal ointment can be used clinically for the treatment of diabetic and nondiabetic wounds.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

Quazi¹,

Patwekar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…For example, regular consumption of apple polyphenols for 12 weeks improved glucose tolerance in adults [ 14 , 15 ]. Despite the fact that several pathways for antidiabetic properties of polyphenolic compounds have been hypothesized, mostly they are based on in vitro research with pharmaceutical doses, which frequently provide misleading or inconsistent outcomes [ 16 , 17 ]. However, nanoformulations of polyphenols have been demonstrated to possess the potentiality for delivering naturally prevailing antidiabetic drugs with poor pharmacological properties compared with alternative dosage forms [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

Islam

Khadija

Islam

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus (DM) is a fatal metabolic disorder, and its prevalence has escalated in recent decades to a greater extent. Since the incidence and severity of the disease are constantly increasing, plenty of therapeutic approaches are being considered as a promising solution. Many dietary polyphenols have been reported to be effective against diabetes along with its accompanying vascular consequences by targeting multiple therapeutic targets. Additionally, the biocompatibility of these polyphenols raises questions about their use as pharmacological mediators. Nevertheless, the pharmacokinetic and biopharmaceutical properties of these polyphenols limit their clinical benefit as therapeutics. Pharmaceutical industries have attempted to improve compliance and therapeutic effects. However, nanotechnological approaches to overcome the pharmacokinetic and biopharmaceutical barriers associated with polyphenols as antidiabetic medications have been shown to be effective to improve clinical compliance and efficacy. Therefore, this review highlighted a comprehensive and up-to-date assessment of polyphenol nanoformulations in the treatment of diabetes and vascular consequences.

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“…In both traditional and contemporary medicine, plants constitute an important source of bioactive chemicals that contribute to the prevention and treatment of disease. Plant-derived products have long been utilized by people all over the world to treat various ailments [ 28 – 30 ]. After going through the above literature, we have designed a work to formulate a polyherbal teabag for the treatment of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Alpha-Amylase Enzyme Assay of Hydroalcoholic Polyherbal Extract: Proof of Concept for the Development of Polyherbal Teabag Formulation for the Treatment of Diabetes

Quazi¹,

Patwekar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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For the treatment and maintenance of postprandial blood glucose increases (i.e., diabetes mellitus), alpha (α)-amylase is a well-known therapeutic target. In this paper, we report an initial exploration of the work, i.e., in vitro alpha-amylase activity of the hydroalcoholic polyherbal extract of the selected plants. After drying, the plant material is ground individually, and at least 100 gm of the crude powder is prepared from each plant. 100 gm of each plant was combined, and a total of 500 gm of the crude powder (Ichnocarpus frutescens (100 gm) + Ficus dalhousie (100 gm) + Crateva magna (100 gm) + Alpinia galangal (100 gm) + Swertia chirata (100 gm)) was prepared to carry out the extraction. This obtained extract was subjected to preliminary phytochemical screening and in vitro alpha-amylase activity. At 16 mg/mL, acarbose displayed 78.40 ± 0.36% inhibition, whereas the extract exhibited 72.96 ± 0.70% inhibition, which is significantly comparable. The IC50 value of acarbose was 12.9 ± 1.12, whereas the extract exhibited 13.31 ± 1.12 mg/mL. The extract possesses numerous classes of chemicals such as alkaloids, glycosides, tannins, polyphenols, and terpenoids, which can contribute to the antidiabetic activity through alpha-amylase inhibition. This was an initial exploration of the work as a proof of concept for the development of polyherbal tea bag formulation for the treatment of diabetes. In the future, we are aiming to investigate the effectiveness of polyherbal tea bags in the treatment of diabetes using more in vitro and in vivo models. From the present investigation, we have concluded that this extract can be used for the treatment of diabetes.

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Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action

Cited by 65 publications

References 187 publications

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

In Vitro Alpha-Amylase Enzyme Assay of Hydroalcoholic Polyherbal Extract: Proof of Concept for the Development of Polyherbal Teabag Formulation for the Treatment of Diabetes

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